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Respiratory muscle senescence in ageing and chronic lung diseases

Joaquim Gea, Pilar Ausín, Juana Ma Martínez-Llorens, Esther Barreiro
European Respiratory Review 2020 29: 200087; DOI: 10.1183/16000617.0087-2020
Joaquim Gea
Dept of Respiratory Medicine, Hospital del Mar – IMIM, DCEXS, Universitat Pompeu Fabra, CIBERES, ISCIII, Barcelona Respiratory Network, Barcelona, Spain
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  • For correspondence: quim.gea@upf.edu
Pilar Ausín
Dept of Respiratory Medicine, Hospital del Mar – IMIM, DCEXS, Universitat Pompeu Fabra, CIBERES, ISCIII, Barcelona Respiratory Network, Barcelona, Spain
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Juana Ma Martínez-Llorens
Dept of Respiratory Medicine, Hospital del Mar – IMIM, DCEXS, Universitat Pompeu Fabra, CIBERES, ISCIII, Barcelona Respiratory Network, Barcelona, Spain
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  • ORCID record for Juana Ma Martínez-Llorens
Esther Barreiro
Dept of Respiratory Medicine, Hospital del Mar – IMIM, DCEXS, Universitat Pompeu Fabra, CIBERES, ISCIII, Barcelona Respiratory Network, Barcelona, Spain
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Figures

  • FIGURE 1
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    FIGURE 1

    Muscle weakness (permanent state) versus muscle fatigue (transient state, solved with rest). NIMV: noninvasive mechanical ventilation; ETIxMV: endotracheal intubation and mechanical ventilation.

  • FIGURE 2
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    FIGURE 2

    Determinants and consequences of muscle ageing. HIF-1: hypoxia-inducible factor-1.

  • FIGURE 3
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    FIGURE 3

    Healthy versus premature ageing. V′/Q′: ventilation/perfusion ratio; PaO2: arterial oxygen tension; PA–aO2: alveolar–arterial oxygen tension difference; ROS: reactive oxygen species.

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Vol 29 Issue 157 Table of Contents
European Respiratory Review: 29 (157)
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Respiratory muscle senescence in ageing and chronic lung diseases
Joaquim Gea, Pilar Ausín, Juana Ma Martínez-Llorens, Esther Barreiro
European Respiratory Review Sep 2020, 29 (157) 200087; DOI: 10.1183/16000617.0087-2020

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Respiratory muscle senescence in ageing and chronic lung diseases
Joaquim Gea, Pilar Ausín, Juana Ma Martínez-Llorens, Esther Barreiro
European Respiratory Review Sep 2020, 29 (157) 200087; DOI: 10.1183/16000617.0087-2020
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  • Article
    • Abstract
    • Abstract
    • Ageing and muscles
    • Muscle function
    • Ageing
    • Comorbidities and ageing
    • Premature senescence
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
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Subjects

  • Lung structure and function
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