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Artificial intelligence in thoracic surgery: past, present, perspective and limits

Harry Etienne, Sarah Hamdi, Marielle Le Roux, Juliette Camuset, Theresa Khalife-Hocquemiller, Mihaela Giol, Denis Debrosse, Jalal Assouad
European Respiratory Review 2020 29: 200010; DOI: 10.1183/16000617.0010-2020
Harry Etienne
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
2Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France
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  • For correspondence: h.etienne@hotmail.fr
Sarah Hamdi
3Dept of Thoracic and Vascular Surgery, Le Raincy-Montfermeil Hospital, Montfermeil, France
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Marielle Le Roux
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
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Juliette Camuset
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
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Theresa Khalife-Hocquemiller
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
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Mihaela Giol
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
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Denis Debrosse
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
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Jalal Assouad
1AP-HP, Dept of Thoracic and Vascular Surgery, Tenon University Hospital, Paris, France
2Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France
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  • FIGURE 1
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    FIGURE 1

    Brief history of artificial intelligence (AI).

  • FIGURE 2
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    FIGURE 2

    Potential applications of artificial intelligence in thoracic surgery in a clinical pathway. CT: computed tomography. The third image is courtesy of https://pngimage.net/. The fourth image represents the Da Vinci Xi surgical robot system (patient's cart and surgeon's console) from Intuitive Surgical.

Tables

  • Figures
  • TABLE 1

    Keywords in artificial intelligence

    Big data
     Data of a very large size, typically to the extent that its manipulation and management present significant logistical challenges which makes it difficult to process it using on-hand data management tools or traditional data processing applications. A multitude of technology platforms may be involved in the generation or collection of this data, including network servers, digital imaging and communications in medicine (DICOM images) stored in picture archiving and communication system (PACS), electronic health records (EHRs), genomic data, personal computers, smart phones and mobile applications, and wearable devices and sensors. Artificial intelligence algorithms present the ability to search through such databases and extract the necessary data for specific task.
    Algorithm
     A set of rules provided to artificial intelligence that allows the machine to perform certain tasks, such as classification.
    Machine learning
     A field of artificial intelligence where a system is taught to interpret various features related to an objective and to flag it when it comes up. It is also trained to make predictions by recognising patterns. Automatic learning enables the machine to improve without continuous support and guidance by employing algorithms based on comparison logic, research and mathematical probability.
    Classifier
    A machine learning algorithm that sorts data into predefined categories. It can be:
     Supervised which means it uses data that has been identified by the programmers to generate predictive models to identify unlabelled data. Often, the algorithm attempts to mimic the ability of a highly trained individual with domain expertise. Unsupervised which requires no data labelling. An output or a target is not defined. The computer looks for patterns or grouping in the data. This approach may be useful in facilitating analysis of big data. Reinforcement learning: the inputs and the outputs pairs are not specified, and the focus of the machine is to perform a task while learning from its own successes and mistakes to improve its performance.
    Neural network
     Neural networks mimic human brain function with each neuron performing its own simple calculation and the network formed by all of the neurons multiplying the potential of these calculations. This technology is particularly useful in predictive analysis, image recognition and speech processing.
    Deep learning
     A subcategory of machine learning where the system is made of digitised inputs, such as an image or speech, which go through multiple layers (ranging from 5 to 1000) of connected “neurons” (neural network), that progressively detect different features, and ultimately provides an output. The results from the first layer of neurons serve as a point of departure for calculating subsequent results. The connected neurons constitute the neural network with autodidactic quality. The system recognises patterns independently and makes predictions on a large quantity of information.
    Natural language processing
     A sub field of artificial intelligence dealing with the way to program computers to process and analyse large amounts of natural language data. Challenges are set by speech recognition, natural language understanding and natural language generation. It employs a sequence of mathematical processes and comparisons to identify the user's input, possibly correcting certain errors or applying synonyms, in order to identify all the information necessary to understand the needs of the user.
  • TABLE 2

    Criteria for public consultation analysis by CNEDiMTS on the use of artificial intelligence (AI) software in medicine

    Final use
     1. Detail the benefit of the information that will be given by the system relying on AI
     2. Describe the characteristics of the population for whom it is intended
    Description of the learning process for the AI
     3. Type of learning method
    •  Continuous (autonomous learning and adaptation)?

    •  Initial (algorithm is trained initially with no further updates)?

    •  Or incremental (algorithm updated through learning process)?

     4. Describe the model used
    •  Supervised?

    •  Semi-supervised?

    •  Unsupervised?

    •  By reinforcement?

     5. Describe the algorithm used
    •  Classification

    •  Regression

    •  Clustering

     6. Describe selection method of the model
     7. Describe the different steps of learning phase
     8. Describe the strategy for updating the algorithm
     9. Describe if necessary in which cases humans intervene in the learning process
    Detail the data entered in the initial learning phase or data involved for the updates or autonomous learning process
    Describe the characteristics of the sample from the targeted population, used to develop the model
     10. Detail the characteristics of the sample
     11. Detail the modalities for separating training data from testing data and validating data
     12. Justify representativeness of the sample chosen compared with the targeted population
    Description of the variables
     13. Characteristics of the variables
    •  Type

    •  Distribution

     14. Origins of the variables and methods of acquisition
    Detail handling of the data before their use for the learning phase
     15. Describe the statistical tests used
     16. Describe methods of transformation use for the data
     17. Describe handling of missing information
     18. Explain detection of erroneous or aberrant data and their handling
    Detail entry data implicated in decision-making
     19. Origins of the variables and methods of acquisition
     20. Characteristics of the variables
    •  Type

    •  Distribution

    Performance
     21. Describe and justify the method of measurement adopted for the performance
     22. Describe the potential impact of adjustments measures
     23. Characterise overfitting and underfitting
     24. Describe the methods to handle overfitting and underfitting
    Validation
     25. Describe the methods of validation
     26. Report the performance of the algorithms on the data set
    Resilience of the system
     27. Describe the mechanisms set up in order to understand model drift
     28. Detail the thresholds chosen
     29. Detail if there is a system to detect any anomaly in the entry data implicated in the decision
     30. Describe the potential impacts of those aberrant entry data
     31. Detail the measure set up in case of model drift
     32. Detail the situations susceptible to alter the system function
    Explainability/interpretability
     33. Does the algorithm benefit from a technique of explainability/interpretability for the patients and/or the physicians?
     34. Detail the elements of explainability available
     35. Identify the influential parameters
     36. Detail if the decision-making in the system follows guidelines when they exist
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Artificial intelligence in thoracic surgery: past, present, perspective and limits
Harry Etienne, Sarah Hamdi, Marielle Le Roux, Juliette Camuset, Theresa Khalife-Hocquemiller, Mihaela Giol, Denis Debrosse, Jalal Assouad
European Respiratory Review Sep 2020, 29 (157) 200010; DOI: 10.1183/16000617.0010-2020

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Artificial intelligence in thoracic surgery: past, present, perspective and limits
Harry Etienne, Sarah Hamdi, Marielle Le Roux, Juliette Camuset, Theresa Khalife-Hocquemiller, Mihaela Giol, Denis Debrosse, Jalal Assouad
European Respiratory Review Sep 2020, 29 (157) 200010; DOI: 10.1183/16000617.0010-2020
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