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Airway mechanical compression: its role in asthma pathogenesis and progression

Punnam Chander Veerati, Jennifer A. Mitchel, Andrew T. Reid, Darryl A. Knight, Nathan W. Bartlett, Jin-Ah Park, Chris L. Grainge
European Respiratory Review 2020 29: 190123; DOI: 10.1183/16000617.0123-2019
Punnam Chander Veerati
1School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
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  • ORCID record for Punnam Chander Veerati
Jennifer A. Mitchel
3Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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Andrew T. Reid
1School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
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Darryl A. Knight
2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
4School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia
5Dept of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
6Research and Academic Affairs, Providence Health Care Research Institute, Vancouver, Canada
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Nathan W. Bartlett
2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
4School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia
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  • ORCID record for Nathan W. Bartlett
Jin-Ah Park
3Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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Chris L. Grainge
1School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
7Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia
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  • For correspondence: christopher.grainge@health.nsw.gov.au
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Article Information

vol. 29 no. 157
DOI 
https://doi.org/10.1183/16000617.0123-2019
PubMed 
32759373

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received September 25, 2019
  • Accepted January 30, 2020
  • Published online August 4, 2020.

Copyright & Usage 
Copyright ©ERS 2020. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Punnam Chander Veerati1,2,
  2. Jennifer A. Mitchel3,
  3. Andrew T. Reid1,2,
  4. Darryl A. Knight2,4,5,6,
  5. Nathan W. Bartlett2,4,
  6. Jin-Ah Park3 and
  7. Chris L. Grainge1,2,7⇑
  1. 1School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
  2. 2Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia
  3. 3Molecular and Integrative Physiological Sciences Program, Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA
  4. 4School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia
  5. 5Dept of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
  6. 6Research and Academic Affairs, Providence Health Care Research Institute, Vancouver, Canada
  7. 7Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia
  1. Chris L. Grainge, School of Medicine and Public Health, The University of Newcastle, Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1, Kookaburra Circuit, New Lambton Heights, NSW, Australia 2305. E-mail: christopher.grainge{at}health.nsw.gov.au
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Vol 29 Issue 157 Table of Contents
European Respiratory Review: 29 (157)
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Airway mechanical compression: its role in asthma pathogenesis and progression
Punnam Chander Veerati, Jennifer A. Mitchel, Andrew T. Reid, Darryl A. Knight, Nathan W. Bartlett, Jin-Ah Park, Chris L. Grainge
European Respiratory Review Sep 2020, 29 (157) 190123; DOI: 10.1183/16000617.0123-2019

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Airway mechanical compression: its role in asthma pathogenesis and progression
Punnam Chander Veerati, Jennifer A. Mitchel, Andrew T. Reid, Darryl A. Knight, Nathan W. Bartlett, Jin-Ah Park, Chris L. Grainge
European Respiratory Review Sep 2020, 29 (157) 190123; DOI: 10.1183/16000617.0123-2019
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Uncontrolled mechanical forces in lung pathophysiology
    • Modelling mechanical compression
    • Experimental models for mechanical compression
    • Mechanical compression activates disease-associated pathways in the airway epithelium
    • Mechanical compression induces airway remodelling
    • Mechanical compression induces epithelial cell unjamming
    • Mechanical compression may impair epithelial anti-viral immunity
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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  • Asthma and allergy
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