Abstract
Chitotriosidase (CHIT1) is a highly conserved and regulated chitinase secreted by activated macrophages; it is a member of the 18-glycosylase family (GH18). CHIT1 is the most prominent chitinase in humans, can cleave chitin and participates in the body's immune response and is associated with inflammation, infection, tissue damage and remodelling processes. Recently, CHIT1 has been reported to be involved in the molecular pathogenesis of pulmonary fibrosis, bronchial asthma, COPD and pulmonary infections, shedding new light on the role of these proteins in lung pathophysiology. The potential roles of CHIT1 in lung diseases are reviewed in this article.
Abstract
This is the first review of chitotriosidase in lung disease http://bit.ly/2LpZUQI
Footnotes
Submitted article, peer reviewed.
Conflict of interest: D. Chang has nothing to disclose.
Conflict of interest: L. Sharma has nothing to disclose.
Conflict of interest: C.S. Dela Cruz has nothing to disclose.
Support statement: The authors gratefully acknowledge financial support from the China Scholarship Council (DC; 201809112037), Beijing Nova Program (DC; Z171100001117012 and 191100001119021), National Institutes of Health National Heart, Lung, and Blood Institute (CDC; R01HL126094), American Legion Auxiliary (LS; 513385) and the American Thoracic Society (LS: 2018-18). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received October 29, 2019.
- Accepted December 2, 2019.
- Copyright ©ERS 2020.
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.