Skip to main content

Main menu

  • Home
  • Current issue
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS author centre
    • COVID-19 submission information
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS author centre
    • COVID-19 submission information
  • Alerts
  • Subscriptions

Dismantling airway disease with the use of new pulmonary function indices

Sabine C. Zimmermann, Katrina O. Tonga, Cindy Thamrin
European Respiratory Review 2019 28: 180122; DOI: 10.1183/16000617.0122-2018
Sabine C. Zimmermann
1Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, Sydney, Australia
3Sydney Medical School Northern, The University of Sydney, Sydney, Australia
4Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sabine C. Zimmermann
Katrina O. Tonga
1Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
2Dept of Respiratory Medicine, Royal North Shore Hospital, Sydney, Australia
3Sydney Medical School Northern, The University of Sydney, Sydney, Australia
4Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
5Dept of Thoracic and Transplant Medicine, St Vincent's Hospital, Sydney, Australia
6Faculty of Medicine, The University of New South Wales, Sydney, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Katrina O. Tonga
Cindy Thamrin
1Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
4Woolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cindy Thamrin
  • For correspondence: cindy.thamrin@sydney.edu.au
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

We are currently limited in our abilities to diagnose, monitor disease status and manage chronic airway disease like asthma and chronic obstructive pulmonary disease (COPD). Conventional lung function measures often poorly reflect patient symptoms or are insensitive to changes, particularly in the small airways where disease may originate or manifest. Novel pulmonary function tests are becoming available which help us better characterise and understand chronic airway disease, and their translation and adoption from the research arena would potentially enable individualised patient care.

In this article, we aim to describe two emerging lung function tests yielding novel pulmonary function indices, the forced oscillation technique (FOT) and multiple breath nitrogen washout (MBNW). With a particular focus on asthma and COPD, this article demonstrates how chronic airway disease mechanisms have been dismantled with the use of the FOT and MBNW. We describe their ability to assess detailed pulmonary mechanics for diagnostic and management purposes including response to bronchodilation and other treatments, relationship with symptoms, evaluation of acute exacerbations and recovery, and telemonitoring. The current limitations of both tests, as well as open questions/directions for further research, are also discussed.

Abstract

Spirometry is used to diagnose and manage airway disease such as asthma and COPD, but relates poorly to symptoms, lacks sensitivity and is effort dependent. FOT and MBNW are emerging clinical lung function tests that help us dismantle disease mechanisms. http://ow.ly/nM0G30nS6Ct

Footnotes

  • Number 1 in the Series “Dismantling Airway Disease” Edited by Sinthia Bosnic-Anticevich and Marc Humbert

  • Provenance: Submitted article, peer reviewed.

  • Author contributions: S.C. Zimmermann, K.O. Tonga and C. Tharmin contributed to the preparation of the manuscript. All authors have read and approved the final manuscript.

  • Conflict of interest: S.C. Zimmermann has nothing to disclose.

  • Conflict of interest: K.O. Tonga has nothing to disclose.

  • Conflict of interest: C. Thamrin has a patent (WO 2006130922 A1) issued and intellectual property arrangements with two FOT device companies, Thorasys Medical Systems and Restech srl relating to scientific collaborations, but does not have any financial relationships with either company.

  • Received December 22, 2018.
  • Accepted February 15, 2019.
  • Copyright ©ERS 2019.
http://creativecommons.org/licenses/by-nc/4.0/

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

View Full Text
PreviousNext
Back to top
View this article with LENS
Vol 28 Issue 151 Table of Contents
European Respiratory Review: 28 (151)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dismantling airway disease with the use of new pulmonary function indices
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Dismantling airway disease with the use of new pulmonary function indices
Sabine C. Zimmermann, Katrina O. Tonga, Cindy Thamrin
European Respiratory Review Mar 2019, 28 (151) 180122; DOI: 10.1183/16000617.0122-2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Dismantling airway disease with the use of new pulmonary function indices
Sabine C. Zimmermann, Katrina O. Tonga, Cindy Thamrin
European Respiratory Review Mar 2019, 28 (151) 180122; DOI: 10.1183/16000617.0122-2018
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Forced oscillation technique
    • Multiple breath nitrogen washout
    • Current limitations and open questions
    • Conclusion
    • Footnotes
    • References
  • Info & Metrics
  • PDF

Subjects

  • Lung imaging
  • COPD and smoking
  • Asthma and allergy
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

Series

  • Genetic disorders of the surfactant system: adult focus
  • Hermansky–Pudlak syndrome pulmonary fibrosis
  • VʹE/VʹCO2 in chronic heart failure
Show more Series

Dismantling Airway Disease

  • Dismantling the pathophysiology of asthma using imaging
Show more Dismantling Airway Disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERR

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising
  • Sponsorship

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN: 0905-9180
Online ISSN: 1600-0617

Copyright © 2021 by the European Respiratory Society