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State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances

Gianluca Sambataro, Domenico Sambataro, Sebastiano Emanuele Torrisi, Ada Vancheri, Mauro Pavone, Roberta Rosso, Matteo Schisano, Claudia Crimi, Francesca Pignataro, Aryeh Fischer, Nicoletta Del Papa, Carlo Vancheri
European Respiratory Review 2018 27: 170139; DOI: 10.1183/16000617.0139-2017
Gianluca Sambataro
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
2Rheumatology Outpatients, accredited with the National Health System, Artroreuma srl, Mascalucia, CT, Italy
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Domenico Sambataro
2Rheumatology Outpatients, accredited with the National Health System, Artroreuma srl, Mascalucia, CT, Italy
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Sebastiano Emanuele Torrisi
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Ada Vancheri
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Mauro Pavone
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Roberta Rosso
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Matteo Schisano
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Claudia Crimi
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Francesca Pignataro
3Day Hospital of Rheumatology, Dept of Rheumatology, ASST G. Pini-CTO, Milan, Italy
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Aryeh Fischer
4Dept of Medicine, University of Colorado School of Medicine, Denver, CO, USA
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Nicoletta Del Papa
3Day Hospital of Rheumatology, Dept of Rheumatology, ASST G. Pini-CTO, Milan, Italy
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Carlo Vancheri
1Regional Referral Centre for Rare Lung Diseases, A.O.U. “Policlinico-Vittorio Emanuele” Dept of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Abstract

The term interstitial pneumonia with autoimmune features (IPAF) has been proposed to define patients with interstitial lung disease (ILD) associated with autoimmune signs not classifiable for connective tissue diseases (CTDs). This new definition overcomes previous nomenclatures and provides a uniform structure for prospective studies through specific classification criteria.

This work evaluates the characteristics of IPAF patients reported in the literature, to highlight potential limits through a comparative analysis and to suggest better performing classification criteria.

Four retrospective studies on the IPAF population have been considered. The study subjects differed in age, sex, smoking habit, ILD pattern and outcomes. Another important difference lies in the diverse items considered in the classification criteria. The retrospective design of the studies and the absence from some of them of a rheumatologist clearly involved in the diagnosis may have influenced the data, but current IPAF criteria seem to include a rather heterogeneous population. To overcome these discrepancies, this review suggests a limitation in the use of single items and the exclusion of extremely specific CTD criteria. This should avoid the definition of IPAF for those diseases at different stages or at early onset. The investigation of a functional or morphological cut-off of pulmonary involvement would be useful.

Abstract

IPAF retrospective cohorts show numerous differences between them. We propose some ideas to improve IPAF criteria http://ow.ly/eubC30jlGJO

Introduction

The interstitial pneumonias comprise a large group of diseases mainly characterised by excessive deposition of collagen matrices in the pulmonary interstitium, inducing a restrictive pattern in pulmonary function tests (PFTs). Some interstitial pneumonias are considered idiopathic, others recognise diverse risk factors, such as smoking, environmental and occupational exposures, while some others are related to connective tissue disease (CTD) [1]. An increasing number of studies have focused on the presence of a particular subset of interstitial pneumonia, apparently idiopathic, associated to one or more clinical and serological features, suggesting a possible underlying autoimmune disorder. Several definitions and nomenclatures have been proposed for this specific form of interstitial pneumonia [2–5], until the recent joint effort of the European Respiratory Society (ERS) and American Thoracic Society (ATS) proposed “interstitial pneumonia with autoimmune features” (IPAF) for this condition [6]. This broadly accepted definition was needed to allow prospective data collection for further studies (complete IPAF classification criteria are reported in table 1).

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TABLE 1

Classification criteria of interstitial pneumonia with autoimmune features

Unfortunately, to date, none of the proposed definitions, focusing on interstitial pneumonia associated with a variety of autoimmune features, consider that pulmonary involvement may be the prevalent, the primary or even the only clinical manifestation of CTDs [7]. In this subset of patients, there may be interstitial pneumonias with some clinical and/or serological characteristics of autoimmune disorders even if they do not satisfy any specific CTD criteria. Indeed, there is a fine line between interstitial pneumonias with autoimmune features and undifferentiated connective tissue diseases (UCTDs).

UCTDs include unclassifiable systemic autoimmune diseases that share clinical and serological features with CTDs, such as systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, dermatomyositis/polymyositis, mixed connective tissue diseases, anti-synthetase syndrome (ASS) and rheumatoid arthritis. Nevertheless, UCTDs do not correspond to any of the specific existing classification criteria [8–15]. The current definitions of UCTD are not yet validated and UCTD is still waiting for well-established classification criteria [16, 17]. Thus, differentiating IPAF from UCTDs would be crucial to better understand the natural history of the diseases, to identify a correct therapeutic approach and to lay the foundation for additional research.

The primary aim of this work was to review the retrospective cohorts of patients classified according to IPAF criteria presented in the literature and evaluate their specific characteristics. Secondarily, we discuss their role in the setting of clinical research and their function as classification criteria.

Materials and methods

Literature search strategy

Two authors independently performed a systematic search of PubMed, Web of Science, the Cochrane database, EBSCO and BioMed Central. Comprehensive searching used the medical subject heading (MeSH) terms “interstitial pneumonia with autoimmune features” and “IPAF” to identify all descriptive works on IPAF patients subsequent to publishing specific criteria, between January 2015 to October 2017. The bibliography of every cited study was checked to identify any additional study suitable for review. We selected only original research articles describing ≥70% of IPAF items. Case reports, case series, letters to editors and reviews were not analysed. From three different articles dealing with the same cohort of IPAF patients, only the one with complete data was considered [18–20]. Finally, manuscripts considering ASS patients were excluded to avoid any selection bias. In spite of the absence of validated classification criteria, ASS is a specific CTD marked by the classic triad composed of ILD, inflammatory arthritis and myositis. Although the clinical triad may be partially present at the time of diagnosis, the majority of patients subsequently develop all clinical signs of ASS during follow-up [21].

Data extraction and quality assessment

Two authors (GS and DS) independently browsed titles, abstracts and full texts meeting the defined criteria. Any discrepancy was resolved by consensus with senior authors (NDP and CV). Each study's clinical characteristics were summarised, and each study's main outcomes were extracted or calculated. The process is reported in figure 1.

FIGURE 1
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FIGURE 1

Inclusion and exclusion of publications identified through database searches. IPAF: interstitial pneumonia with autoimmune features.

Statistical analysis

All statistical analyses were performed using Prism 7.0 software (GraphPad, San Diego, CA, USA). Continuous variables were compared using t-tests. z-tests were used to compare population proportions to identify any difference in clinical characteristics or in items of IPAF classification criteria.

Results

Four studies satisfied the selection criteria, reporting complete clinical, serological and morphological characteristics of IPAF patients.

In the first study, Oldham et al. [18] identified 144 patients affected by IPAF from a population of 422 suffering from idiopathic interstitial pneumonia or CDT-ILD. This IPAF population had a mean age of 63 years; about half of them presented usual interstitial pneumonia (UIP) as prevalent radiological and/or histological pattern of idiopathic interstitial pneumonia. Complete clinical features are reported in table 2. For classification criteria, 14.6% of the population met both clinical and serological domains, 8.3% presented clinical and morphological domains and 26.4% met all three domains. An overall analysis showed a mortality for IPAF similar to idiopathic pulmonary fibrosis (IPF) (39.6% died and 10.8% underwent lung transplantation). However, stratifying for prevalent high-resolution chest tomography (HRCT) pattern, only UIP-IPAF resembled IPF, while non-UIP-IPAF showed a significantly better outcome, similar to CTD-ILD. In the multivariate analysis, age and diffusing capacity of the lung for carbon monoxide were associated with worse prognosis.

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TABLE 2

Patient clinical characteristics and clinical domains reported in studies

Chartrand et al. [22] reported an IPAF population of 56 patients, with a mean age of 54.6 years and mainly nonsmokers. The prevalent HRCT and surgical lung biopsy pattern resulted in nonspecific interstitial pneumonia (NSIP) (51.8%), and UIP was reported in ∼9% of patients. More than half of patients met criteria for all three domains, 37.5% of patients were classified for serological and morphological domains, 9% were classified for clinical and morphological domains and 1.5% (only one patient) classified for serological and clinical domains. The most frequent clinical features were Raynaud's phenomenon (39.3%), mechanic's hands (28.6%) and Gottron's sign (17.9%). In the serological domain, the most common positive features were antinuclear antibody (ANA) (48.2%), anti-Ro/Sjögren syndrome-A (42.9%) and the anti-tRNA synthetase antibody (ATSA) family (35.7%). As for outcomes, the authors reported no mortality during follow-up (duration of 284.9±141.3 weeks) without any new clinical or serological criteria for specific CTDs.

Ahmad et al. [23] described a population of 57 IPAF patients. Among them, 11.1% showed clinical and serological signs, 7% clinical and morphological signs, 52.7% serological and morphological signs and 29.2% showed signs from all three domains. IPAF patients presented a mean age of 64.4±14 years with no sex predominance, and 34% of them were smokers. The most frequent HRCT patterns were NSIP (42.1%) and UIP (28%), whereas the most frequent multicompartment involvement was pulmonary vasculopathy (17.5%). Over a median follow-up period of 16 months, seven patients died. The multivariate analysis revealed only smoking habit as a predictive factor of worse prognosis and no significant difference between UIP and NSIP pattern.

The last contribution, produced by Ito et al. [24], investigated 99 patients with IPAF. The only patient with a UIP pattern and at least one clinical and serological criterion for IPAF was excluded. Among the residual 98 patients, 64.3% showed an NSIP pattern, 20.4% organising pneumonia and the remaining 15.3% an NSIP+OP pattern. This work was mainly directed at understanding the prognosis of these patients, describing a 5-year survival of 71.1% with a median of 12.5 years. The negative prognostic factors were age and NSIP pattern, rather than the presence of specific antibodies. Moreover, 12 (12.2%) patients developed a definite CTD (mainly rheumatoid arthritis).

Comparative analysis

Our analysis included 355 patients affected by IPAF (257 matching the clinical domain). Comparative analyses of the studies showed significant differences between the IPAF cohorts.

Chartrand et al. [22] described the youngest population (p<0.0001 compared with others), and the highest percentage of females (p=0.03 versus Oldham et al. [18] and p=0.01 versus Ahmad et al. [23], but similar to Ito et al. [24]). In the study by Oldham et al. [18], the population included the highest proportion of smokers (p=0.03 versus Chartrand et al. [22], p=0.01 versus Ahmad et al. [23] and p=0.01 versus Ito et al. [24]) and the lowest proportion of patients treated with corticosteroids (p<0.0001).

Regarding UIP pattern, each study is different from the others, with the highest percentage in the population of Oldham et al. [18] population and the lower in the study by Ito et al. [24] (table 2).

The populations in the studies by Oldham et al. [18] and Ahmad et al. [23] showed significantly higher proportions of patients meeting the clinical and serological criteria (p=0.01 and p=0.03, respectively) and significantly lower proportions of patients presenting all three domains (p=0.0006 and p=0.01, respectively) compared to Chartrand et al. [22] (table 2).

Taking into account the IPAF criteria in clinical domains, the population in the study by Chartrand et al. [22] showed a higher proportion of mechanic's hand and Gottron's sign compared to those by Ahmad et al. [23] and Oldham et al. [18] (p=0.0003 and p=0.001; and p=0.03 and p=0.003, respectively). A complete comparison is reported in table 2.

Considering the serological domain, the population in the study by Chartrand et al. [22] showed the lowest proportion of ANA positivity (considering a minimum titre of 1:320 for any pattern and any titre for centromeric and nucleolar patterns) (p<0.0001 compared to Oldham et al. [18] and Ito et al. [24]; p=0.0001 compared to Ahmad et al. [23]). Conversely, the population in Chartrand et al. [22] showed a significantly higher proportion of anti-Ro/Sjögren syndrome-A, anti-RNP, anti-Smith and ATSA antibodies compared to the other studies (table 3). Unlike other investigators, Ito et al. considered rheumatoid factor to be positive when it was three times (not twice, as reported in IPAF criteria) the cut-off value; even so, they presented the highest proportion of rheumatoid factor.

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TABLE 3

Comparison of serological domains

For the morphological domain, the populations in the studies by Chartrand et al. [22] and Ito et al. [24] presented higher proportions of patients with significantly higher presence of NSIP patterns (p=0.009 compared to Oldham et al. [18] and p=0.001 compared to Ahmad et al. [23]) (complete comparison is presented in table 4). Finally, for patient outcomes, as expected considering the higher proportion of UIP patients, the population in the study by Oldham et al. [18] showed the highest mortality rate (39.6%) compared to those in the studies by Chartrand et al. [22] (p<0.0001) and Ito et al. [24] (p=0.0007), but the latter population, despite a comparable HRCT pattern, showed significantly worse prognosis compared to the population in the study by Chartrand et al. [22] (p<0.0001, table 2). In addition, differences in terms of treatment were reported. The population in the study by Chartrand et al. [22] shows the highest percentage of treated patients (p=0.001).

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TABLE 4

Comparison of morphological domains

In addition, Oldham et al. [18] performed a further stratification by HRCT pattern. Non-UIP IPAF patients had a prognosis very similar to those with CTD-ILD, whereas the progression of the disease in UIP-IPAF patients was resembled IPF.

However, these data were not confirmed by Ahmad et al., who reported a similar prognosis for IPAF and IPF patients.

Discussion

Classification criteria are standardised definitions with the primary aim of creating homogeneous cohorts for research [25]. In this way, they favour high specificity over sensitivity. In 2015, the IPAF criteria [6] were created via consensus opinion by an expert international panel of 13 pulmonologists, four rheumatologists, one thoracic radiologist and one pulmonary pathologist. Importantly, the panel was largely composed by the same investigators who had previously put forth criteria for ILD with autoimmune characteristics. The IPAF criteria, endorsed by the ATS and ERS proposed a research classification for interstitial pneumonia patients who presented at least one specific feature from at least two of the following three domains: clinical, serological and morphological. The proposed IPAF classification has the advantage of removing previous nomenclatures, creating a framework to study a more uniform population in a readily applicable manner worldwide.

Comparing the already reported IPAF cohorts, in our analysis we identified very different populations from the clinical, serological and morphological point of view. In addition, some differences were noted in terms of outcomes. As expected, mortality was higher in the Oldham et al. [18] cohorts, where more patients had a UIP pattern. However, in the other studies, mortality was not strictly related to the presence of a UIP pattern.

Obviously, comparison of different studies may have limitations. The first one is related to the retrospective nature of the reviewed cohorts, which can, at least in part, explain the numerous differences highlighted observed among them. In fact, IPAF criteria were proposed for prospective studies and data from these will be of pivotal interest. A second limitation is related to the lack of a rheumatologist clearly involved in the multidisciplinary team (MDT). Chartrand et al. [22] reported the presence of an expert rheumatologist in the diagnostic process, whereas in the other studies this role was not clearly involved in diagnosis. This difference may explain the reason why the cohort in the Chartrand et al. study has features and outcomes similar to CTD, whereas patients in the Oldham et al. cohort have features and outcomes more similar to IPF. A third weakness concerns treatment. Oldham et al. did not report any patient treatment. The other studies gave only a partial description of how patients were treated. In some cases, they were treated with steroids and/or immunosuppressant drugs according to the low prevalence of UIP pattern. Furthermore, despite the similarity of the HRCT pattern in the Ito et al. [24] and Chartrand et al. populations, a low percentage of treated patients and a worse prognosis was observed in the former cohort. These data may suggest the importance of treatment in the evolution and prognosis of IPAF patients.

Nevertheless, in the absence of proper prospective studies, the comparison and analysis of these four retrospective studies give some useful insights that may be helpful to improve the current IPAF classification.

As described, IPAF criteria overlap UCTD criteria as well as those criteria that identify early onset or incomplete forms of defined CTDs [16, 17, 26]. These disorders might be called “IPAF” inappropriately, while they represent different diseases at different stages. For instance, criteria for very early diagnosis of systemic sclerosis (VEDOSS) [26] are able to identify individuals with a high risk of developing a defined systemic sclerosis. These patients are of great interest, considering that their evident “sclerodermic flavour” allows the timing of onset of the disease to be studied, or whether the presence or even the absence of an item in the pathogenic behaviour influences complete disease manifestation.

Although criteria for very early diagnosis of other CTDs are not yet defined, IPAF criteria can capture all these forms under a unique definition. In this context, it should be considered that different CTDs, even at early stages, have different pathogenic pathways and varying evolution.

Moreover, IPAF criteria may include patients with ASS. Patients with a positive ATSA and ILD could be considered to have ASS by some clinicians and IPAF by others, despite the high risk of developing other clinical findings of the classic triad (arthritis and/or myositis) [21]. In this regard, it seems important to consider the mutual concept: ILD patients should be tested for all ATSA and other antibodies linked to inflammatory myopathies, although some of these antibodies are not widely available.

Thus, the current definition of IPAF is not probably able to select homogenous populations. On the contrary, in the context of the MDT follow-up, IPAF classification is useful in selecting subsets of ILD patients at risk of developing a defined CTD.

Another point of view could be that IPAF is a primary autoimmune disease, which mainly focuses on the lung. To sustain this hypothesis, it is necessary to satisfy Koch's postulate for autoimmune diseases [27] by demonstrating autoreactive T- or B-cells (specific antibodies). In support of this thesis, IPAF populations show higher proportions of ANA positivity than expected in the general population [28]. Moreover, antibodies useful for diagnosing CTD showed their primary autoantigen sources in the lung, such as Jo-1 and anti-citrullinated protein antibody (ACPA) [29–31]. In some other cases, antibodies are associated with prevalent lung involvement, such as ATSA and anti-Th/To [32, 33], and in IPF autoantibodies are less rare [34, 35].

In our opinion, IPAF criteria should follow the latter hypothesis to avoid the inappropriate inclusion of IPAF patients with several different clinical conditions.

In this light, the presence in these criteria of very specific items (such as Extractable Nuclear Antigen (ENA) specificities, anti-double stranded DNA, ACPA, distal digital tip ulceration, mechanic's hands) or even pathognomonic features, such as Gottron's sign [36], for definite CTDs appear to be not useful. Similarly, in spite of the lack of classification criteria for ASS, patients with ILD and myositis show positivity for ATSA up to 60% of cases [15]. Therefore, it may not be by chance that the Chartrand et al. [22] population showed simultaneously a higher prevalence of Gottron's sign, mechanic's hands, NSIP pattern and ATSA, four features all linked to inflammatory myopathies.

Conversely, other antibodies associated with a wide spectrum of autoimmune diseases and ILD such as anti-neutrophil cytoplasmic antibodies (ANCA) [37] and anti-Ku antibody should be considered [38, 39]. Furthermore, some reports described patients with ANCA-positive interstitial pneumonia. Currently, limited data are available for this subset of patients. Yamada [40] reviewed the reported cohorts, describing 92 patients with interstitial pneumonia generally classifiable as IPF with positivity for ANCA. In this cohort, 35.8% of patients showed concurrent ANCA-associated vasculitis (AAV), 17.4% developed an AAV with a delay of years compared to the interstitial pneumonia and the remaining 46.8% showed only ANCA-positive interstitial pneumonia. These patients had a prevalence of honeycombing in surgical lung biopsy with a prognosis similar to IPF. Few other patients had signs of bronchiolar or interstitial vasculitis. The author hypothesised two pathogenic mechanisms. The first is that subclinical alveolar haemorrhage can contribute to interstitial pneumonia in AAV. The second mechanism considered the high prevalence of anti-myeloperoxidase (MPO) ANCA in these patients. In response to inflammatory cytokines, MPO is shown to the surface of neutrophils, and can be bound by circulating ANCA, with subsequent neutrophil degranulation and release of reactive oxygen species, leading to injury and fibrosis. This second mechanism might explain ANCA-associated interstitial pneumonia without vasculitis.

In addition, this optimisation of the number of diagnostic items could avoid some confusion in classification. Particular attention should be paid to the possible association of autoimmune features during the classification of a single patient. In several cases, patients with combined positivity for high titre of rheumatoid factor and ACPA were considered to have IPAF. This combination exposes general and high-risk populations to a 100% likelihood of developing rheumatoid arthritis in 5 years [41]. Furthermore, in the Ahmad et al. [23] population, patients with sicca syndrome and minor salivary gland biopsy suggestive of Sjögren syndrome were classified as having IPAF. In these cases, the likelihood of developing technically detectable clinical impairment of salivary or lacrimal glands and fulfilling Sjögren syndrome criteria is very high. Besides, in the same study, patients with Raynaud's phenomenon, giant capillaries at nailfold videocapillaroscopy (NVC) and NSIP pattern were classified as having IPAF rather than VEDOSS. The authors specified that NVC was considered positive for minor alterations [42, 43], but giant capillaries, as reported in the manuscript, is one of the most specific items for CTD in NVC, with well documented significance in diagnosis and prognosis [44–47]. As such, abnormal NVC may be considered as an exclusion criterion for IPAF classification.

An improvement in specificity can be obtained with a more precise definition of the morphological domain. For example, it could be enriched adding a quantification cut-off in terms of PFTs. This may explain the frequent variability of ILD in CTDs reported in the literature. An interesting study on rheumatoid arthritis reported ILD in 19% of patients, but only 6% of these showed a restrictive PFT pattern [48]. In the remaining patients, it cannot be excluded that the aetiological cause of ILD may not be autoimmune and already solved at diagnosis. The use of thresholds may improve specificity at the expense of the sensitivity of the IPAF criteria, with more chances to create a homogeneous population.

Moreover, the concept of “unexplained intrinsic airways disease” could benefit from clarification, especially regarding bronchiectasis, reported as an example of unexplained intrinsic airways disease. Its finding is extremely common in the ILDs, especially in the UIP pattern [49], hence this parameter is not useful to discriminate among patients.

In the light of these considerations, IPAF criteria could be potentially refined as follows. 1) Exclusion of items extremely specific for CTD and simplification of criteria; 2) inclusion in the serological domain of ANCA and anti-Ku antibodies; 3) evaluation of positive NVC as an exclusion criterion of IPAF; 4) definition of a PFT cut-off to consider ILD as clinically significant/at risk of progression; 5) clarification of the multicompartment involvement section (mainly intrinsic airway disease); and 6) active involvement of a rheumatologist in the MDT.

Footnotes

  • Provenance: Submitted article, peer reviewed.

  • Conflict of interest: C. Vancheri reports grants and personal fees from Roche and Boehringer Ingelheim, outside the submitted work.

  • Conflict of interest: A. Fischer reports personal fees (consultancy and steering committee) from Boehringer Ingelheim and F Hoffman La Roche, during the conduct of the study.

  • Received December 22, 2017.
  • Accepted March 29, 2018.
  • Copyright ©ERS 2018.

ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

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State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances
Gianluca Sambataro, Domenico Sambataro, Sebastiano Emanuele Torrisi, Ada Vancheri, Mauro Pavone, Roberta Rosso, Matteo Schisano, Claudia Crimi, Francesca Pignataro, Aryeh Fischer, Nicoletta Del Papa, Carlo Vancheri
European Respiratory Review Jun 2018, 27 (148) 170139; DOI: 10.1183/16000617.0139-2017

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State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances
Gianluca Sambataro, Domenico Sambataro, Sebastiano Emanuele Torrisi, Ada Vancheri, Mauro Pavone, Roberta Rosso, Matteo Schisano, Claudia Crimi, Francesca Pignataro, Aryeh Fischer, Nicoletta Del Papa, Carlo Vancheri
European Respiratory Review Jun 2018, 27 (148) 170139; DOI: 10.1183/16000617.0139-2017
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