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A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators

Stefano Ponzano, Giulia Nigrelli, Laura Fregonese, Irmgard Eichler, Fabio Bertozzi, Tiziano Bandiera, Luis J.V. Galietta, Marisa Papaluca
European Respiratory Review 2018 27: 170124; DOI: 10.1183/16000617.0124-2017
Stefano Ponzano
1European Medicines Agency, London, UK
2D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genova, Italy
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Giulia Nigrelli
1European Medicines Agency, London, UK
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Laura Fregonese
1European Medicines Agency, London, UK
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Irmgard Eichler
1European Medicines Agency, London, UK
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Fabio Bertozzi
2D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genova, Italy
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Tiziano Bandiera
2D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genova, Italy
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Luis J.V. Galietta
3Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
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Marisa Papaluca
1European Medicines Agency, London, UK
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Article Information

vol. 27 no. 148
DOI 
https://doi.org/10.1183/16000617.0124-2017
PubMed 
29653946

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received November 6, 2017
  • Accepted February 14, 2018
  • Published online April 13, 2018.

Copyright & Usage 
Copyright ©ERS 2018. ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Stefano Ponzano1,2,
  2. Giulia Nigrelli1,
  3. Laura Fregonese1,
  4. Irmgard Eichler1,
  5. Fabio Bertozzi2,
  6. Tiziano Bandiera2,
  7. Luis J.V. Galietta3 and
  8. Marisa Papaluca1
  1. 1European Medicines Agency, London, UK
  2. 2D3 PharmaChemistry, Istituto Italiano di Tecnologia, Genova, Italy
  3. 3Telethon Institute of Genetics and Medicine, Pozzuoli, Italy
  1. Stefano Ponzano, Clinical Pharmacology and Non-clinical Support Office, Specialised Scientific Disciplines Dept, European Medicines Agency, 30 Churchill Place, Canary Wharf, London, E14 5EU, UK. E-mail: stefano.ponzano{at}ema.europa.eu
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Vol 27 Issue 148 Table of Contents
European Respiratory Review: 27 (148)
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A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators
Stefano Ponzano, Giulia Nigrelli, Laura Fregonese, Irmgard Eichler, Fabio Bertozzi, Tiziano Bandiera, Luis J.V. Galietta, Marisa Papaluca
European Respiratory Review Jun 2018, 27 (148) 170124; DOI: 10.1183/16000617.0124-2017

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A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators
Stefano Ponzano, Giulia Nigrelli, Laura Fregonese, Irmgard Eichler, Fabio Bertozzi, Tiziano Bandiera, Luis J.V. Galietta, Marisa Papaluca
European Respiratory Review Jun 2018, 27 (148) 170124; DOI: 10.1183/16000617.0124-2017
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Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Current therapies for CF
    • Trends in CF drug development
    • Analysis of nonclinical end-points in the light of the clinical results of CFTR modulators
    • Conclusions and recommendations
    • Supplementary material
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • CF and non-CF bronchiectasis
  • Pulmonary pharmacology and therapeutics
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More in this TOC Section

  • Protecting healthcare workers from SARS-COV-2 infections
  • Bronchiectasis: case-based investigation and management
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