Figures
- FIGURE 1
Bronchiolocentric fibrosis. a) This low power view shows fibrosis of peribronchiolar alveolar septa. Scale bar=500 µm. b) A higher power view shows peribronchiolar metaplasia with lining of the bronchiolocentric alveolar septa by ciliated columnar respiratory epithelium. Scale bar=200 µm.
- FIGURE 2
Nonspecific interstitial pneumonia. a) This low power view shows diffuse alveolar septal thickening by moderate interstitial fibrosis. Scale bar=1 mm. b) A higher power view shows the architectural preservation of lung tissue. Scale bar=500 µm.
- FIGURE 3
Usual interstitial pneumonia. a) This low power view shows the heterogeneous pattern of fibrosis with subpleural microscopic honeycombing and centrilobular lack of alveolar inflammation or fibrosis. Scale bar=2 mm. b) A high power view shows a fibroblast focus with typical layered appearance within a loose myxoid stroma. Scale bar=100 µm.
- FIGURE 4
Unclassifiable interstitial fibrosis. This low power view shows patchy fibrosis with subpleural and bronchiolocentric accentuation as well as prominent lymphoid aggregates. Further clinical history for this 68-year-old woman suggested the likely multidisciplinary diagnosis was nitrofurantoin toxicity. Scale bar= 2 mm.
- FIGURE 5
Unclassifiable interstitial fibrosis. This low power view shows patchy fibrosis with focal microscopic honeycombing, airspace enlargement, scattered lymphoid aggregates, and central nonspecific interstitial pneumonia fibrosis-like changes. Further clinical history for this 49-year-old woman with early greying of hair and a sibling with pulmonary fibrosis suggested the likely diagnosis was familial interstitial pulmonary fibrosis. Scale bar=2 mm.
Tables
- TABLE 1
Multidisciplinary diagnosis of patients pathologically unclassifiable by surgical lung biopsy
Cases n Number of surgical lung biopsies performed: 849 Number of non-diagnostic biopsies: 2 Number with pathologic diagnosis of “fibrosing interstitial pneumonia: unclassifiable”: 41 Final multidisciplinary diagnosis n Unclassifiable: 19 Idiopathic pulmonary fibrosis: 8 Chronic hypersensitivity pneumonia: 5 Autoimmune connective tissue disease: 4 Smoking-related interstitial lung disease: 2 Infection (Mycobacterium avium): 1 Sarcoidosis: 1 Idiopathic nonspecific interstitial pneumonia: 1
Jump To
- Article
- Abstract
- Abstract
- Introduction
- Surgical lung biopsy: reducing pre-histological barriers to classification
- Typical patterns of fibrosis
- Physiological basis of the typical patterns of fibrosis
- Histological sources of unclassifiable interstitial fibrosis
- Post-biopsy evaluation: the MDD
- Conclusions
- Footnotes
- References
- Figures & Data
- Info & Metrics