Figures
- FIGURE 1
Differential response to treatment between two phenotypes of acute respiratory distress syndrome. a) High and low positive end-expiratory pressure (PEEP); b) conservative and liberal fluid management.
Tables
- TABLE 1
Ventilatory and pharmacological management of acute respiratory distress syndrome (ARDS) per responsive phenotype
Intervention Suggested/recommended Responsive phenotype NIV Recommended Early phase of respiratory failure, with rapid response after start of NIV Tracheotomy Suggested Prolonged mechanical ventilation Low tidal volumes Recommended All patients with ARDS Plateau pressure <30 cmH2O Recommended All patients with ARDS Driving pressure <15 cmH2O Suggested All patients with ARDS High PEEP strategy Recommended PaO2/FIO2 <200 Prone position Recommended PaO2/FIO2 <150 Neuromuscular blocking agents Recommended PaO2/FIO2 <150 and first 48 h of ARDS Extracorporeal membrane oxygenation Suggested Patients requiring rescue therapy Glucocorticosteroids Suggested No responsive phenotype identified NIV: noninvasive ventilation; PEEP: positive end-expiratory pressure; PaO2: arterial oxygen tension; FIO2: inspiratory oxygen fraction.
Supplementary Material
L.D. Bos ERR-0107-2017_Bos
Vol 27 Issue 147
Table of Contents
ARDS: challenges in patient care and frontiers in research
