Abstract
The development of targeted therapies has transformed the outlook for patients with pulmonary arterial hypertension (PAH); however, some patients fail to achieve an adequate clinical response despite receiving maximal treatment. For these patients, lung transplantation remains an important therapeutic option, and recommendations for transplantation are included in the current European Society of Cardiology/European Respiratory Society guidelines for the diagnosis and treatment of pulmonary hypertension. Although lung transplantation is not without risk, overall long-term survival rates are good and substantial improvements in quality of life have been reported for lung transplant recipients. In this review, we describe the important considerations prior to, during and after transplantation, including the role of mechanical support, in patients with advanced PAH.
Abstract
Lung transplantation and mechanical support play key therapeutic roles in patients with advanced PAH http://ow.ly/mqfG30gMcMd
Footnotes
Support statement: M.M. Hoeper is supported by the Deutsche Forschungsgemeinschaft (DFG: HO 1599/2-1). Funding was received from Actelion Pharmaceuticals Ltd, Allschwil, Switzerland. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: Disclosures can be found alongside this article at err.ersjournals.com
Provenance: Publication of this peer-reviewed article was sponsored by Actelion Pharmaceuticals Ltd, Allschwil, Switzerland (principal sponsor, European Respiratory Review issue 146).
- Received August 16, 2017.
- Accepted November 22, 2017.
- Copyright ©ERS 2017.
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