Figures
- FIGURE 1
Radiology assessment of pulmonary amyloidosis. a) Computed tomography (CT) scan of the chest of a patient with nodular pulmonary amyloidosis; b) diffuse interstitial pulmonary amyloidosis in a patient with light-chain amyloidosis: high-resolution CT of the chest shows diffuse subpleural septal thickening.
Tables
- TABLE 1
Common types of systemic amyloidosis
Precursor protein Acquired/hereditary Organ involvement Symptoms and signs Treatment Systemic AL Monoclonal LCs Acquired; caused by plasma cell clone All organs (except the brain) Depend on organ involved Chemotherapy, ASCT Localised AL Monoclonal LCs Acquired; caused by plasma cell clone Tracheobronchial tree, lungs, urinary bladder, skin (others) Depend on location Localised therapy ATTRwt Wild-type transthyretin Acquired; age-related Heart, soft tissue, lung Heart failure Heart failure therapy (new therapies) ATTRm Mutated transthyretin Hereditary Heart, PNS/ANS Heart failure and peripheral neuropathy Liver transplant (new therapies) AA Apolipoprotein serum amyloid A Acquired; reactive to chronic inflammation Heart, kidney, liver, lung Nephrotic syndrome Treatment of underlying condition The amyloid types are identified by acronyms where the letter “A” for amyloidosis is followed by the abbreviation of the protein forming the amyloid fibrils. LCs: immunoglobulin light chains; ASCT: autologous stem cell transplant; PNS: peripheral nervous system; ANS: autonomic nervous system.
