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An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan

Henning Gall, Marius M. Hoeper, Manuel J. Richter, William Cacheris, Barbara Hinzmann, Eckhard Mayer
European Respiratory Review 2017 26: 160121; DOI: 10.1183/16000617.0121-2016
Henning Gall
1Universities of Giessen and Marburg Lung Centre (UGMLC), member of the German Centre for Lung Research (DZL), Giessen, Germany
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  • For correspondence: henning.gall@innere.med.uni-giessen.de
Marius M. Hoeper
2Clinic for Respiratory Medicine, Hannover Medical School, member of the German Centre for Lung Research (DZL), Hannover, Germany
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Manuel J. Richter
1Universities of Giessen and Marburg Lung Centre (UGMLC), member of the German Centre for Lung Research (DZL), Giessen, Germany
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William Cacheris
3Tessellon Inc., St Louis, MO, USA
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Barbara Hinzmann
4Bayer AG, Berlin, Germany
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Eckhard Mayer
5Kerckhoff Heart and Lung Centre, Bad Nauheim, Germany
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  • FIGURE 1
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    FIGURE 1

    Proportion of patients who develop chronic thromboembolic pulmonary hypertension (CTEPH) following pulmonary embolism (PE). #: studies followed-up individual patients after PE.

  • FIGURE 2
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    FIGURE 2

    a) Annual diagnosed incidence of pulmonary embolism (PE), and b) annual full incidence of chronic thromboembolic pulmonary hypertension (CTEPH) per 100 000 population in Europe, the USA and Japan (crude rates for the year 2015).

  • FIGURE 3
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    FIGURE 3

    Distribution of patients with chronic thromboembolic pulmonary hypertension by New York Heart Association functional class (NYHA FC) at time of diagnosis by region. EU: European Union.

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    FIGURE 4

    Proportions of patients with chronic thromboembolic pulmonary hypertension (CTEPH) who were diagnosed in Europe, the USA and Japan in 2013.

Tables

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  • TABLE 1

    Projected estimates of the annual incidence of full and diagnosed cases of chronic thromboembolic pulmonary hypertension (CTEPH) in Europe, the USA and Japan

    20152025
    Full incidence of CTEPHDiagnosed incidence of CTEPHFull incidence of CTEPHDiagnosed incidence of CTEPH
    France331065037441154
    Germany38796744065934
    Italy27475292975905
    Spain16031331833357
    UK20876172347956
    USA16 566200019 5314543
    Japan244473225131356
    Total32 636533437 00910 205
    NYHA FC III/IV38606393
    • Data are presented as n. NYHA FC: New York Heart Association functional class.

Supplementary Materials

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    Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.

    Supplementary table S1, and figures S1 and S2 ERR-0121-2016_Supplementary_data

  • Supplementary Material

    W. Cacheris ERR-0121-2016_Cacheris

    H. Gall ERR-0121-2016_Gall

    B. Hinzmann ERR-0121-2016_Hinzmann

    M.M. Hoeper ERR-0121-2016_Hoeper

    E. Mayer ERR-0121-2016_Mayer

    M.J. Richter ERR-0121-2016_Richter

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European Respiratory Review: 26 (143)
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An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan
Henning Gall, Marius M. Hoeper, Manuel J. Richter, William Cacheris, Barbara Hinzmann, Eckhard Mayer
European Respiratory Review Mar 2017, 26 (143) 160121; DOI: 10.1183/16000617.0121-2016

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An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan
Henning Gall, Marius M. Hoeper, Manuel J. Richter, William Cacheris, Barbara Hinzmann, Eckhard Mayer
European Respiratory Review Mar 2017, 26 (143) 160121; DOI: 10.1183/16000617.0121-2016
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