Figures
- FIGURE 1
Imaging and histological correlation in lung adenocarcinoma classification. a) Computed tomography (CT) scan demonstrating a ground-glass nodule that on resection represents adenocarcinoma in situ. b) The preserved alveolar architecture is seen at low magnification in this adenocarcinoma in situ. Scale bar=3 mm. c) CT scan demonstrating a solid area surrounded by a rim of ground-glass attenutation. d) On resection, this was an acinar predominant adenocarcinoma with gland formation seen on the histology image.
- FIGURE 2
Imaging and histological correlation in lung adenocarcinoma classification. a) Computed tomography (CT) scan demonstrating a solid attenuation nodule. b) A micropapillary pattern with small nests of tumours cells surrounded by retraction artefact was seen on the resection specimen. Scale bar=50 μm. c) Papillary pattern is shown with fibrovascular cores and an arborising architecture lined by neoplastic cells. Scale bar=100 μm. d) On the right side a solid tumour nest demonstrating solid pattern adenocarcinoma is seen. A typical feature of lung adenocarcinoma heterogeneity is shown by an adjacent focus on the left showing micropapillary pattern.
Tables
- TABLE 1
Studies of predominant histology and outcome: mixed stages
First author [ref.] 5-year survival AIS/MIA Lepidic Acinar Papillary Solid Micropapillary DFS DSS OS DFS DSS OS DFS DSS OS DFS DSS OS DFS DSS OS DFS DSS OS Murakami [20] 100 99 81 82 74 33 Hung [23]# 80 90 90 70 90 70 70 90 70 40 70 60 50 70 50 Tsao [24]#,¶ 60 60 60 55 60 55 35 45 35 45 Russell [15] 86 68 71 39 38 Tsuta [14] 98 93 67 74 58 62 Yoshizawa [25] 100 100 99 100 70 81 67 75 43 40 0 42 Warth [13] 73 80 79 62 79 67 35 56 49 51 66 58 34 60 45 Gu [17] 100 100 72 91 54 72 56 72 46 58 25 46 AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; DFS: disease-free survival; DSS: disease-specific survival; OS: overall survival. #: data estimated from Kaplan–Meier curves; ¶: papillary/acinar combined, solid/micropapillary combined.
- TABLE 2
Studies of predominant histology and outcome: stage I only
First author [ref.] 5-year survival AIS/MIA Lepidic Acinar Papillary Solid Micropapillary DFS OS DFS OS DFS OS DFS OS DFS OS DFS OS Yang [26] 95 83 92 67 58 Yoshiya [27]#,¶ 98 98 88 97 88 97 64 85 64 85 Yoshizawa [25] 100 74 90 75 84 75 83 75 70 61 67 61 Hung [23]+ >90 100 80 80 80 80 60 75 60 NA AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; DFS: disease-free survival; OS: overall survival; NA: not available. #: papillary/acinar combined, solid/micropapillary combined; ¶: 3-year survival; +: data estimated from Kaplan–Meier curves.
