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Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives

Prakash Chelladurai, Werner Seeger, Soni Savai Pullamsetti
European Respiratory Review 2016 25: 135-140; DOI: 10.1183/16000617.0036-2016
Prakash Chelladurai
1Max-Planck-Institute for Heart and Lung Research, Dept of Lung Development and Remodeling, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
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Werner Seeger
1Max-Planck-Institute for Heart and Lung Research, Dept of Lung Development and Remodeling, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
2University of Giessen Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany
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Soni Savai Pullamsetti
1Max-Planck-Institute for Heart and Lung Research, Dept of Lung Development and Remodeling, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
2University of Giessen Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany
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  • For correspondence: soni.pullamsetti@mpi-bn.mpg.de
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Article Information

vol. 25 no. 140 135-140
DOI 
https://doi.org/10.1183/16000617.0036-2016
PubMed 
27246590

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received April 19, 2016
  • Accepted May 6, 2016
  • Published online May 31, 2016.

Copyright & Usage 
Copyright ©ERS 2016. ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Prakash Chelladurai1,
  2. Werner Seeger1,2 and
  3. Soni Savai Pullamsetti1,2⇑
  1. 1Max-Planck-Institute for Heart and Lung Research, Dept of Lung Development and Remodeling, member of the German Center for Lung Research (DZL), Bad Nauheim, Germany
  2. 2University of Giessen Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig University, Giessen, Germany
  1. Soni Savai Pullamsetti, Max-Planck-Institute for Heart and Lung Research, Dept of Lung Development and Remodeling, Parkstrasse-1, 61231-Bad Nauheim, Germany. E-mail: soni.pullamsetti{at}mpi-bn.mpg.de
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Vol 25 Issue 140 Table of Contents
European Respiratory Review: 25 (140)
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Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives
Prakash Chelladurai, Werner Seeger, Soni Savai Pullamsetti
European Respiratory Review Jun 2016, 25 (140) 135-140; DOI: 10.1183/16000617.0036-2016

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Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives
Prakash Chelladurai, Werner Seeger, Soni Savai Pullamsetti
European Respiratory Review Jun 2016, 25 (140) 135-140; DOI: 10.1183/16000617.0036-2016
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Epigenetics
    • Role of epigenetic mechanisms in PAH
    • DNA methylation
    • Histone post-translational modifications
    • Deregulation of HDAC isoforms and therapeutic evaluation
    • Mixed results of HDAC inhibition in the right ventricle
    • Bromodomain-containing proteins and therapeutic evaluation
    • Concluding remarks
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

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  • Pulmonary vascular disease
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