Lee, 2013 [34] | II | 240 | Pemetrexed + erlotinib | 7.4 | | 20.5 | | 44.7 | |
Erlotinib | 3.8 | 0.002 | 22.8 | 0.747 | 29.3 | 0.031 |
Pemetrexed | 4.4 | 0.005 | 17.7 | 0.168 | 10.0 | <0.001 |
Dittrich, 2014 [35] | II | 165 | Pemetrexed + erlotinib | 3.19 | 0.0047 | 11.8 | 0.019 | 17.1 | 0.180 |
Pemetrexed | 2.89 | | 7.75 | | 10.8 | |
Hanna, 2013 [55] | III | 713 | Pemetrexed + nintedanib | 4.4 | 0.0435 | 12.2 | | 9.1 | |
Pemetrexed + placebo | 3.6 | | 12.8 | | 8.3 | |
de Boer, 2011 [51] | III | 534 | Pemetrexed + vandetanib | 4.4 | 0.108 | 9.2 | 0.219 | 19.1 | <0.001 |
Pemetrexed + placebo | 2.9 | | 10.5 | | 7.9 | |
Kim, 2013 [36] | III | 938 | Pemetrexed + cetuximab | 2.9 | 0.76 | 6.9 | 0.86 | 7 | 0.20 |
Pemetrexed | 2.8 | | 7.8 | | 4 | |
Docetaxel + cetuximab | 2.4 | 0.39 | 5.8 | 0.31 | 8 | 0.68 |
Docetaxel | 1.5 | | 8.2 | | 7 | |
Schiller, 2010 [39] | II | 148 | Pemetrexed + matuzumab LD | 2.3 | | 12.4 | | 16 | |
Pemetrexed + matuzumab HD | 2.5 | | 5.9 | | 2 | |
Pemetrexed | 2.7 | | 7.9 | | 4 | |
Chiappori, 2010 [57] | II | 160 | Pemetrexed + enzastaurin | 3.0 | 0.544 | 9.6 | 0.171 | 3.9 | |
Pemetrexed + placebo | 3.0 | | 7.4 | | 2.6 | |
Jänne, 2013 [44] | II | 87 | Docetaxel + selumetinib | 5.3 | 0.014 | 9.4 | 0.21 | 37.2 | <0.001 |
Docetaxel + placebo | 2.1 | | 5.2 | | 0 | |
Ramlau, 2012 [49] | III | 913 | Docetaxel + aflibercept | 5.2 | 0.0035 | 10.1 | 0.90 | 23.3 | <0.001 |
Docetaxel + placebo | 4.1 | | 10.4 | | 8.9 | |
Herbst, 2010 [52] | III | 1391 | Docetaxel + vandetanib | 4.0 | <0.0001 | 10.3 | 0.371 | 17 | 0.0001 |
Docetaxel + placebo | 3.2 | | 9.9 | | 10 | |
Reck, 2014 [56] | III | 1314 | Docetaxel + nintedanib | 3.4 | 0.0019 | 10.1 | 0.2720 | 4.4 | 0.3067 |
Docetaxel + placebo | 2.7 | | 9.1 | | 3.3 | |
Garon, 2014 [50] | III | 1253 | Docetaxel + ramucirumab | 4.5 | <0.0001 | 10.5 | 0.023 | 23 | <0.0001 |
Docetaxel + placebo | 3.0 | | 9.1 | | 14 | |
Herbst, 2007 [47] | II | 120 | Docetaxel/pemetrexed + bevacizumab | 4.8 | | 12.6 | | 12.5 | |
Erlotinib + bevacizumab | 4.4 | | 13.7 | | 17.9 | |
Docetaxel/pemetrexed | 3.0 | | 8.6 | | 12.2 | |