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Pulmonary hypertension in patients with chronic myeloproliferative disorders

Yochai Adir, Davide Elia, Sergio Harari
European Respiratory Review 2015 24: 400-410; DOI: 10.1183/16000617.0041-2015
Yochai Adir
1Pulmonary Division, Carmel Medical Center, Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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  • For correspondence: adir-sh@zahav.net.il
Davide Elia
2U.O. di Pneumologia e Terapia Semi-Intensiva, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, MultiMedica IRCSS, Milan, Italy
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Sergio Harari
2U.O. di Pneumologia e Terapia Semi-Intensiva, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe, MultiMedica IRCSS, Milan, Italy
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Abstract

Pulmonary hypertension (PH) is a major complication of several haematological disorders. Chronic myeloproliferative diseases (CMPDs) associated with pulmonary hypertension have been included in group five of the clinical classification for pulmonary hypertension, corresponding to pulmonary hypertension for which the aetiology is unclear and/or multifactorial. The aim of this review is to discuss the epidemiology, pathogenic mechanism and treatment approaches of the more common forms of pulmonary hypertension in the context of CMPD's: chronic thromboembolic pulmonary hypertension, precapillary pulmonary hypertension and drug-induced PH.

Abstract

Epidemiology, pathogenic mechanism and treatment approach of PH in patients with chronic myeloproliferative diseases http://ow.ly/Q1QX4

Footnotes

  • Conflict of interest: Disclosures can be found alongside the online version of this article at err.ersjournals.com

  • Provenance: Publication of this peer-reviewed article was sponsored by F. Hoffman-La Roche Ltd, Basel, Switzerland (principal sponsor, European Respiratory Review issue 137).

  • Received May 14, 2015.
  • Accepted July 23, 2015.
  • Copyright ©ERS 2015.

ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

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Pulmonary hypertension in patients with chronic myeloproliferative disorders
Yochai Adir, Davide Elia, Sergio Harari
European Respiratory Review Sep 2015, 24 (137) 400-410; DOI: 10.1183/16000617.0041-2015

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Pulmonary hypertension in patients with chronic myeloproliferative disorders
Yochai Adir, Davide Elia, Sergio Harari
European Respiratory Review Sep 2015, 24 (137) 400-410; DOI: 10.1183/16000617.0041-2015
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Epidemiology
    • Chronic thromboembolic pulmonary hypertension
    • Precapillary pulmonary hypertension
    • Drug-induced PH
    • Conclusion
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    • References
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