Figures
- FIGURE 1
Suggested areas corresponding to severe α1-antitrypsin (AAT) deficiency (below the protective threshold) and intermediate AAT deficiency (above the protective threshold and below the 10th percentile of the AAT range for subjects carrying the PI*MS genotype). Bars represent the 5th and 95th percentiles of AAT serum levels. Even MZ can have normal serum levels. Reproduced from [3] with permission from the publisher.
- FIGURE 2
Cumulative mortality over 60 months in patients with α1-antitrypsin deficiency and an initial forced expiratory volume in 1 s <50% predicted who never (n=382), partially (n=357) or always (n=390) received augmentation therapy. Reproduced with modification from [8] with permission from the publisher.
- FIGURE 3
Change from baseline in total lung capacity (TLC)-adjusted 15th percentile lung density (PD15) over the course of the study. The error bars indicate sem. Estimated treatment difference in mean slopes (annual change in lung density) 0.857 (p=0.068). Reproduced with modification from [13] with permission.
Tables
- TABLE 1
Commercially available preparations of purified α1-antitrypsin
Drug Manufacturer Source Dedicated pathogen safety steps Regulatory approval Prolastin Grifols (Barcelona, Spain) Pooled human plasma Pasteurisation Austria, Belgium, Denmark, Finland, Germany, Greece, Ireland, Italy, Netherlands, Norway, Poland, Portugal, Spain, Sweden and Switzerland Prolastin C Grifols (Barcelona, Spain) Pooled human plasma S/D purification + nanofiltration USA, Canada, Argentina and Colombia Trypsone Grifols (Barcelona, Spain) Pooled human plasma S/D purification + nanofiltration Spain, Argentina, Brazil, Chile and Mexico Aralast NP Baxter (Deerfield, IL, USA) Pooled human plasma S/D purification + nanofiltration USA Zemaira CSL Behring (King of Prussia, PA, USA) Pooled human plasma Pasteurisation + nanofiltration USA and Brazil Glassia Kamada (Ness Ziona, Israel) Pooled human plasma S/D purification + nanofiltration USA and Brazil Alfalastin LFB (Courtabœuf, France) Pooled human plasma Pasteurisation France S/D: solvent/detergent. Data from [6].
Disclosures
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