Association and clinical implications |
Elevated systemic inflammation, e.g. interleukin-6, C-reactive protein |
Use of long-term oxygen therapy |
Increase in the number of comorbidities |
Prolongs length of hospital stay |
Increase in the number of consultations with general practitioners |
Morbidity and mortality |
Female sex |
Escalates frequency of hospital readmission |
Heightens the number of acute exacerbations |
Severe respiratory impairment |
Cachexia |
Symptoms |
Health-endangering behaviour (smoking) |
Increased fatigue |
Panic |
Social withdrawal |
Lack of interest in pleasurable activities |
Fear |
Dyspnoea on exertion |
Insomnia |
Somonolence |
Impact on physical and social functioning |
Reduced exercise capacity |
Increased physical disability |
Reduced social interaction |
Dependence on caregivers |
Emotional liability |
Loss of social role |
Loss of libido |
Decrease in cognitive functioning |
Early retirement from work |
Loss of self-esteem |
Treatment options |
Support and adherence to exercise and antidepressant treatment |
Pulmonary rehabilitation |
Personalised intervention |
Collaborative care model |
Counselling |
Exercise |
Smoking cessation |
Relaxation therapy |
Antidepressant drug therapy |
Psychotherapy (cognitive behavioural and supportive) |
Yoga |
Social support and respite care for caregivers |
Telephone health mentoring using cognitive behavioural therapy |