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First-line treatment of EGFR-mutated nonsmall cell lung cancer: critical review on study methodology

Martin Sebastian, Alexander Schmittel, Martin Reck
European Respiratory Review 2014 23: 92-105; DOI: 10.1183/09059180.00008413
Martin Sebastian
1Dept of Hematology/Oncology, University Hospital Frankfurt, Frankfurt, 2Hematology, Oncology, Infectious Diseases, Aerzteforum Seestrasse, Medizinisches Versorgungszentrum, Berlin, and 3LungClinic Grosshansdorf, Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.
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  • For correspondence: martin.sebastian@kgu.de
Alexander Schmittel
1Dept of Hematology/Oncology, University Hospital Frankfurt, Frankfurt, 2Hematology, Oncology, Infectious Diseases, Aerzteforum Seestrasse, Medizinisches Versorgungszentrum, Berlin, and 3LungClinic Grosshansdorf, Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.
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Martin Reck
1Dept of Hematology/Oncology, University Hospital Frankfurt, Frankfurt, 2Hematology, Oncology, Infectious Diseases, Aerzteforum Seestrasse, Medizinisches Versorgungszentrum, Berlin, and 3LungClinic Grosshansdorf, Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.
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Article Information

vol. 23 no. 131 92-105
DOI 
https://doi.org/10.1183/09059180.00008413
PubMed 
24591666

Published By 
European Respiratory Society
Print ISSN 
0905-9180
Online ISSN 
1600-0617
History 
  • Received November 29, 2013
  • Accepted December 20, 2013
  • Published online February 28, 2014.

Copyright & Usage 
©ERS 2014 ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 3.0.

Author Information

  1. Martin Sebastian1⇑,
  2. Alexander Schmittel2 and
  3. Martin Reck3
  1. 1Dept of Hematology/Oncology, University Hospital Frankfurt, Frankfurt, 2Hematology, Oncology, Infectious Diseases, Aerzteforum Seestrasse, Medizinisches Versorgungszentrum, Berlin, and 3LungClinic Grosshansdorf, Member of the German Centre for Lung Research (DZL), Grosshansdorf, Germany.
  1. M. Sebastian, Dept of Hematology/Oncology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Frankfurt, Germany. E-mail: martin.sebastian{at}kgu.de
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Vol 23 Issue 131 Table of Contents
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First-line treatment of EGFR-mutated nonsmall cell lung cancer: critical review on study methodology
Martin Sebastian, Alexander Schmittel, Martin Reck
European Respiratory Review Mar 2014, 23 (131) 92-105; DOI: 10.1183/09059180.00008413

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First-line treatment of EGFR-mutated nonsmall cell lung cancer: critical review on study methodology
Martin Sebastian, Alexander Schmittel, Martin Reck
European Respiratory Review Mar 2014, 23 (131) 92-105; DOI: 10.1183/09059180.00008413
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  • Article
    • Abstract
    • Introduction
    • Methodology
    • Quantitative and qualitative analyses of phase III first-line trials in EGFR mutation-positive NSCLC
    • Limitations of comparisons across trials
    • Limitations of source data
    • Limitations of trial methodology
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • Pulmonary pharmacology and therapeutics
  • Lung cancer
  • Lung biology and experimental studies
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