Rosenberg–Patterson criteria [73,#74] |
Major criteria |
Asthma |
Presence of transient pulmonary infiltrates (fleeting shadows) |
Immediate cutaneous reactivity to Aspergillus fumigatus |
Elevated total serum IgE |
Precipitating antibodies against A. fumigatus |
Peripheral blood eosinophilia |
Elevated serum IgE and IgG to A. fumigatus |
Central/proximal bronchiectasis with normal tapering of distal bronchi |
Minor criteria |
Expectoration of golden brownish sputum plugs |
Positive sputum culture for Aspergillus species |
Late (Arthus type) skin reactivity to A. fumigatus |
Minimal essential criteria [19] |
Asthma |
Immediate cutaneous reactivity to A. fumigatus |
Total serum IgE >1000 ng·mL−1 (417 kU·L−1) |
Elevated specific IgE-/IgG to A. fumigatus |
Central bronchiectasis in the absence of distal bronchiectasis |
Truly minimal criteria [18] |
Asthma |
Immediate cutaneous reactivity to A. fumigatus |
Total serum IgE >1000 ng·mL−1 (417 kU·L−1) |
Central bronchiectasis in the absence of distal bronchiectasis |
ISHAM working group [68] |
Predisposing conditions |
Bronchial asthma |
Cystic fibrosis |
Obligatory criteria (both should be present) |
Type I Aspergillus skin test positive (immediate cutaneous hypersensitivity to Aspergillus antigen) or elevated IgE levels against A. fumigatus |
Elevated total IgE levels (>1000 IU·mL−1)# |
Other criteria (at least two of three) |
Presence of precipitating or IgG antibodies against A. fumigatus in serum |
Radiographic pulmonary opacities consistent with ABPA |
Total eosinophil count >500 cells·μL−1 in steroid naïve patients (may be historical) |