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Fibrocytes in pulmonary fibrosis: a brief synopsis

Shyam Maharaj, Chiko Shimbori, Martin Kolb
European Respiratory Review 2013 22: 552-557; DOI: 10.1183/09059180.00007713
Shyam Maharaj
1Firestone Institute for Respiratory Health, Depts of Medicine, McMaster University, Hamilton, ON, Canada. 2Dept of Pharmacology, Shimane University School of Medicine, Shimane, Japan.
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Chiko Shimbori
1Firestone Institute for Respiratory Health, Depts of Medicine, McMaster University, Hamilton, ON, Canada. 2Dept of Pharmacology, Shimane University School of Medicine, Shimane, Japan.
1Firestone Institute for Respiratory Health, Depts of Medicine, McMaster University, Hamilton, ON, Canada. 2Dept of Pharmacology, Shimane University School of Medicine, Shimane, Japan.
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Martin Kolb
1Firestone Institute for Respiratory Health, Depts of Medicine, McMaster University, Hamilton, ON, Canada. 2Dept of Pharmacology, Shimane University School of Medicine, Shimane, Japan.
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  • For correspondence: kolbm@mcmaster.ca
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Abstract

Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue by various chemokines. It is likely that fibrocytes play a detrimental role in tissue homeostasis and promote fibrosis, although this paradigm needs further confirmation. This would make fibrocytes a possible novel treatment target for fibrotic disorders. Fibrocytes also have some potential as a biomarker for idiopathic pulmonary fibrosis (IPF) and other diseases, but the promising preliminary data from single centre studies still require independent validation. Despite several, as yet, unresolved issues, it has become clear that fibrocytes are more than an incidental finding in lung injury and repair, and may hold great promise for the future of IPF management.

Footnotes

  • Conflict of interest: Disclosures can be found alongside the online version of this article at err.ersjournals.com

  • Provenance: Submitted article, peer reviewed.

  • Received October 10, 2013.
  • Accepted October 21, 2013.
  • ©ERS 2013

ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 3.0.

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Fibrocytes in pulmonary fibrosis: a brief synopsis
Shyam Maharaj, Chiko Shimbori, Martin Kolb
European Respiratory Review Dec 2013, 22 (130) 552-557; DOI: 10.1183/09059180.00007713

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Fibrocytes in pulmonary fibrosis: a brief synopsis
Shyam Maharaj, Chiko Shimbori, Martin Kolb
European Respiratory Review Dec 2013, 22 (130) 552-557; DOI: 10.1183/09059180.00007713
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  • Article
    • Abstract
    • Introduction
    • Pulmonary fibrosis
    • Progenitor cells and fibrocytes in tissue repair and fibrosis
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  • Mechanisms of lung disease
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