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The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension

Sean Gaine, Gérald Simonneau
European Respiratory Review 2013 22: 487-494; DOI: 10.1183/09059180.00006213
Sean Gaine
1National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland. 2Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France.
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  • For correspondence: sgaine@mater.ie
Gérald Simonneau
1National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland. 2Service de Pneumologie, Hôpital Universitaire de Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France.
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    Figure 1.

    Relationship between the mean 6-min walk distance at baseline and the rate of fatal events during follow-up. Reproduced from [24] with permission from the publisher.

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    Figure 2.

    Kaplan–Meier survival estimates in patients with pulmonary arterial hypertension stratified by median 6-min walk distance (6MWD) after 4 months of bosentan monotherapy. Reproduced from [21] with permission from the publisher.

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    Figure 3.

    Relationship between change in 6-min walk distance (Δ6MWD) and a) composite outcome, b) all-cause mortality, c) hospitalisation for pulmonary arterial hypertension and/or lung or heart–lung transplantation, and d) initiation of pulmonary arterial hypertension rescue therapy. Reproduced from [29] with permission from the publisher.

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    Figure 4.

    Effect of macitentan on morbidity and mortality. #: risk reduction 30%, hazard ratio 0.70, p=0.01. ¶: risk reduction 45%, hazard ratio 0.55, p<0.001. Reproduced from [31] with permission from the publisher.

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The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension
Sean Gaine, Gérald Simonneau
European Respiratory Review Dec 2013, 22 (130) 487-494; DOI: 10.1183/09059180.00006213

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The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension
Sean Gaine, Gérald Simonneau
European Respiratory Review Dec 2013, 22 (130) 487-494; DOI: 10.1183/09059180.00006213
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  • Article
    • Abstract
    • Introduction
    • Relationship between 6MWD and long-term outcomes
    • Use of a composite primary end-point consisting of morbidity and mortality events as an alternative to 6MWD
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
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Subjects

  • Pulmonary pharmacology and therapeutics
  • Pulmonary vascular disease
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