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Smoking cessation and COPD

Philip Tønnesen
European Respiratory Review 2013 22: 37-43; DOI: 10.1183/09059180.00007212
Philip Tønnesen
Dept of Pulmonary Medicine, Gentofte Hospital, Copenhagen, Denmark
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Abstract

The mainstay in smoking cessation is counselling in combination with varenicline, nicotine replacement therapy (NRT) or bupropion SR. Varenicline and combination of two NRTs is equally effective, while varenicline alone is more effective than either NRT or bupropion SR. NRT is extremely safe but cardiovascular and psychiatric adverse events with varenicline have been reported. These treatments have also been shown to be effective in patients with chronic obstructive pulmonary disease (COPD).

A model study is the Lung Health Study from the USA. Findings from this study of 5,587 patients with mild COPD showed that repeated smoking cessation for a period of 5 yrs resulted in a quit rate of 37%. After 14.5 yrs the quitters had a higher lung function and a higher survival rate. A study with a new nicotine formulation, a mouth spray, showed high relative efficacy. As 5–10% of quitters use long-term NRT, we report the results of a study where varenicline compared with placebo increased the quit rate in long-term users of NRT.

Smoking cessation is the most effective intervention in stopping the progression of COPD, as well as increasing survival and reducing morbidity. This is why smoking cessation should be the top priority in the treatment of COPD.

  • Bupropion
  • chronic obstructive pulmonary disease
  • counselling
  • nicotine replacement therapy
  • smoking cessation
  • varenicline

Footnotes

  • Provenance

    Submitted article, peer reviewed.

  • Statement of Interest

    P. Tønnesen has received fees for speaking about smoking cessation from Johnson & Johnson and McNeil, he has received fees for participating in advisory boards from Pfizer and GSK, and he has participated in smoking cessation studies sponsored by Pfizer and McNeil.

  • Received December 2, 2012.
  • Accepted December 17, 2012.
  • ©ERS 2013
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Smoking cessation and COPD
Philip Tønnesen
European Respiratory Review Mar 2013, 22 (127) 37-43; DOI: 10.1183/09059180.00007212

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Smoking cessation and COPD
Philip Tønnesen
European Respiratory Review Mar 2013, 22 (127) 37-43; DOI: 10.1183/09059180.00007212
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  • Article
    • Abstract
    • SMOKING PREVALENCE IN COPD PATIENTS
    • NICOTINE ADDICTION AND SMOKING
    • SMOKING CESSATION TREATMENTS
    • COUNSELLING
    • PHARMACOTHERAPY
    • RE-TREATMENT IN COPD PATIENTS
    • CONCLUSION
    • Footnotes
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