Treat-to-target approach in pulmonary arterial hypertension: a consensus-based proposal
Olivier Sitbon, Adolfo Baloira Villar, Fabrice Bauer, Björn Ekmehag, Wendy Gin-Sing, Kjell Jansson, David G. Kiely, Hanno Leuchte, Alessandra Manes, Stephan Rosenkranz, Pilar Escribano
European Respiratory Review 2012 21: 259-262; DOI: 10.1183/09059180.00003612
Olivier Sitbon
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Adolfo Baloira Villar
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Fabrice Bauer
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Björn Ekmehag
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Wendy Gin-Sing
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Kjell Jansson
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
David G. Kiely
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Hanno Leuchte
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Alessandra Manes
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Stephan Rosenkranz
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
Pilar Escribano
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
*Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
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vol. 21 no. 125 259-262
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- Published online August 31, 2012.
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- Olivier Sitbon*,#¶⇓,
- Adolfo Baloira Villar+,
- Fabrice Bauer§,f,
- Björn Ekmehag**,##,
- Wendy Gin-Sing¶¶,
- Kjell Jansson++§§,
- David G. Kielyff,
- Hanno Leuchte***,
- Alessandra Manes###,
- Stephan Rosenkranz¶¶¶ and
- Pilar Escribano+++§§§
- *Université Paris-Sud, Faculté de Médecine, #AP-HP, Centre de Référence de l‘Hypertension Pulmonaire Sévère, Service de Pneumologie, CHU de Bicêtre, Le Kremlin-Bicêtre, ¶INSERM U999, IPSIT, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, §Centre de Compétences de l'Hypertension Pulmonaire, Service de Cardiologie, Pôle Thorax, Hôpital Charles-Nicolle, and fUniversité de Rouen, Faculté de Médecine, INSERM 1096, Rouen, France. +Dept of Pneumology, Hospital Montecelo, Pontevedra, +++Pulmonary Hypertension Unit, Hospital Universitario 12 de Octubre, §§§Dept of Medicine, Universidad Complutense de Madrid, Madrid, Spain. **Norrtälje Hospital, Norrtälje, ##Dept of Cardiology, Lund University, Lund, ++Depts of Cardiology and Physiology, Linköping University Hospital, §§IMH Linköping University, Linköping, Sweden. ¶¶Dept of Cardiology, Hammersmith Hospital, London, ffSheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK. ***Medical Dept II, Neuwittelsbach Hospital, Munich, ¶¶¶Klinik III für Innere Medizin, Universität zu Köln, Cologne, Germany, ###Institute of Cardiology, Università di Bologna, Bologna, Italy.
- O. Sitbon, Service de Pneumologie, CHU de Bicêtre, 78 rue du General Leclerc, 94270 Le Kremlin-Bicêtre, France. E-mail: olivier.sitbon{at}bct.aphp.fr
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Treat-to-target approach in pulmonary arterial hypertension: a consensus-based proposal
Olivier Sitbon, Adolfo Baloira Villar, Fabrice Bauer, Björn Ekmehag, Wendy Gin-Sing, Kjell Jansson, David G. Kiely, Hanno Leuchte, Alessandra Manes, Stephan Rosenkranz, Pilar Escribano
European Respiratory Review Sep 2012, 21 (125) 259-262; DOI: 10.1183/09059180.00003612
Treat-to-target approach in pulmonary arterial hypertension: a consensus-based proposal
Olivier Sitbon, Adolfo Baloira Villar, Fabrice Bauer, Björn Ekmehag, Wendy Gin-Sing, Kjell Jansson, David G. Kiely, Hanno Leuchte, Alessandra Manes, Stephan Rosenkranz, Pilar Escribano
European Respiratory Review Sep 2012, 21 (125) 259-262; DOI: 10.1183/09059180.00003612