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An update on paediatric asthma

Gunilla Hedlin, Jon Konradsen, Andrew Bush
European Respiratory Review 2012 21: 175-185; DOI: 10.1183/09059180.00003212
Gunilla Hedlin
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
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  • For correspondence: gunilla.hedlin@ki.se
Jon Konradsen
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
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Andrew Bush
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
*Dept of Women's and Children's Health, Karolinska Institutet #Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden. ¶Dept of Paediatrics, Royal Brompton Hospital and +Dept of Paediatric Respiratory Medicine, Imperial College, London, UK.
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    Figure 1.

    Clinical classification of children presenting with problematic severe asthma.

Tables

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  • Table 1. Possible differential diagnosis in a child presenting with severe asthma
    Tracheomalacia
    Congenital disorders
    Primary ciliary dyskinesia
    Oesophageal fistula
    Foreign body
    Bronchiolitis
    Immunodeficiency
    Cardiac disease
  • Table 2. Treatment regimens for the TREXA study
    GroupSubjects nRegular therapyExacerbation therapy
    171BDP 50 μg twice a dayBDP 100 μg/β2-rescue
    272PlaceboBDP 100 μg/β2-rescue
    371BDP 50 μg twice a dayPlacebo/β2-rescue
    474PlaceboPlacebo/β2-rescue
    • TREXA: TReating Children to Prevent Exacerbations of Asthma; BDP: beclomethasone diproprionate.

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An update on paediatric asthma
Gunilla Hedlin, Jon Konradsen, Andrew Bush
European Respiratory Review Sep 2012, 21 (125) 175-185; DOI: 10.1183/09059180.00003212

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An update on paediatric asthma
Gunilla Hedlin, Jon Konradsen, Andrew Bush
European Respiratory Review Sep 2012, 21 (125) 175-185; DOI: 10.1183/09059180.00003212
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  • Article
    • NOTES ON EPIDEMIOLOGY
    • DEFINITIONS AND DIAGNOSIS OF SEVERE ASTHMA
    • ASTHMA COMORBIDITIES AND/OR ASSOCIATED DIAGNOSIS
    • UPDATE ON MECHANISMS OF ASTHMA IN CHILDREN
    • ASSESSMENT AND BIOMARKERS OF ASTHMA
    • RECENT ADVANCES IN THE TREATMENT OF ASTHMA IN CHILDREN
    • ADHERENCE TO TREATMENT
    • CONCLUSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
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  • Paediatric pulmonology
  • Asthma and allergy
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  • Pulmonary manifestations of Sjögren's syndrome
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