Tables
- Table 1. Diagnosis of idiopathic pulmonary fibrosis based on a combination of high-resolution computed tomography (HRCT) and histopathology patterns
HRCT pattern Histopathology pattern UIP Probable UIP Possible UIP Non-classifiable fibrosis Not UIP UIP Yes Yes Yes Yes No Possible UIP Yes Yes Probable Probable No Not UIP Possible No No No No UIP: usual interstitial pneumonia. Modified from [1, 76] with permission from the publisher.
- Table 2. Patterns of disease behaviour
Self-limited inflammation Drug-induced lung disease (acute onset)
Hypersensitivity pneumonitis (short-term exposure)
Sarcoidosis (distinct subset with usually acute onset)
COP, DIP and LIPStable fibrotic disease Drug-induced lung disease (residual fibrosis after cessation)
Hypersensitivity pneumonitis (after prolonged exposure)
Sarcoidosis (residuum of burnt-out fibrotic disease)
Non-progressive pneumoconiosis after cessation of exposure (e.g. silicosis)
NSIPMajor inflammation, risk of fibrotic progression Drug-induced lung disease (unusually florid reactions)
Hypersensitivity pneumonitis (usually continuing exposure)
Sarcoidosis (prolonged severe inflammation)
NSIP, COP, LIP and DIPInexorably progressive fibrosis Drug-induced lung disease (continuing exposure)
Hypersensitivity pneumonitis (antigen usually unknown)
Sarcoidosis (small subset of patients)
Progressive pneumoconiosis after exposure (e.g. asbestosis)
UIPExplosive acute diffuse lung disease Drug-induced lung disease
AIPCOP: cryptogenic organising pneumonia; DIP: desquamative interstitial pneumonia; LIP: lymphocytic interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; UIP: usual interstitial pneumonia; AIP: acute interstitial pneumonia.
Vol 21 Issue 123
Table of Contents
Recent advances in the pathogenesis and clinical evaluation of pulmonary fibrosis
