FIGURE 5. Long-term outcome in pulmonary arterial hypertension (PAH) patients according to baseline and 4-month 6-min walk distance (6MWD). a) Kaplan–Meier survival estimates in 103 patients with idiopathic (i)PAH grouped by the baseline 6MWD. Survival rates for patients with a baseline value >330 m (––––––) were 98, 98 and 91% at 1, 2 and 3 yrs, respectively, compared with 86, 79 and 66%, respectively, for patients with a baseline value <330 m (-----; p = 0.002 by Cox–Mantel log-rank test). b) Kaplan–Meier survival estimates in 99 patients with iPAH grouped by the 6MWD after 4 months of bosentan monotherapy. Survival rates for patients with a value >378 m after 4 months (———) were 100, 100 and 90% at 1, 2 and 3 yrs, respectively, compared with 85, 79 and 69%, respectively, for patients with a value <378 m (-----; p = 0.005 by Cox–Mantel log-rank test) after 4 months. Reproduced and modified from [9] with permission from the publisher.