Challenges in the diagnosis and treatment of pulmonary arterial hypertension

JL Vachiéry, S Gaine - European respiratory review, 2012 - Eur Respiratory Soc
Advances in the diagnosis and management of pulmonary arterial hypertension (PAH) have
resulted in significant improvements in outcomes for patients with this devastating and …

Pulmonary arterial hypertension: tailoring treatment to risk in the current era

S Gaine, V McLaughlin - European Respiratory Review, 2017 - Eur Respiratory Soc
Recent advances in the treatment of pulmonary arterial hypertension (PAH) have led to
improved patient outcomes. Multiple PAH therapies are now available and optimising the …

Diagnosis, treatment, and clinical management of pulmonary arterial hypertension in the contemporary era: a review

BA Maron, N Galiè - JAMA cardiology, 2016 - jamanetwork.com
Importance Pulmonary arterial hypertension (PAH) is characterized by severe remodeling of
the distal pulmonary arteries, increased pulmonary vascular resistance, and right ventricular …

How to detect disease progression in pulmonary arterial hypertension

JL Vachiery, P Yerly, S Huez - European Respiratory Review, 2012 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a rapidly progressive disease, ultimately leading to
right heart failure and death. Accumulating evidence indicates that intervention early in …

Diagnosis and management of pulmonary arterial hypertension: Implications for respiratory care

DJ Levine - Respiratory care, 2006 - rc.rcjournal.com
Pulmonary arterial hypertension (PAH) is a pathological condition of the small pulmonary
arteries. PAH is characterized histopathologically by vasoconstriction, vascular proliferation …

Pulmonary arterial hypertension: bridging the present to the future

M Humbert, R Souza, N Galiè… - European …, 2012 - Eur Respiratory Soc
The past decade has witnessed extensive progress in basic and clinical research in the field
of pulmonary hypertension (PH), a group of chronic conditions characterised by high …

Clinical trial design and new therapies for pulmonary arterial hypertension

O Sitbon, M Gomberg-Maitland… - European …, 2019 - Eur Respiratory Soc
Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on
case reports and small series, and was largely ineffectual. As a deeper understanding of the …

Epidemiology and treatment of pulmonary arterial hypertension

EMT Lau, E Giannoulatou, DS Celermajer… - Nature Reviews …, 2017 - nature.com
In the past 2 decades, major changes have occurred in the epidemiological and treatment
landscape of pulmonary arterial hypertension (PAH). Previously regarded as a disease of …

General measures and supportive therapy for pulmonary arterial hypertension: Updated recommendations from the Cologne Consensus Conference 2018

E Grünig, N Benjamin, U Krüger, H Kaemmerer… - International journal of …, 2018 - Elsevier
In the summer of 2016, delegates from the German Respiratory Society, the German Society
of Cardiology and the German Society of Pediatric Cardiology met in Cologne, Germany, to …

Beyond a single pathway: combination therapy in pulmonary arterial hypertension

O Sitbon, S Gaine - European Respiratory Review, 2016 - Eur Respiratory Soc
There is a strong rationale for combining therapies to simultaneously target three of the key
pathways implicated in the pathogenesis of pulmonary arterial hypertension (PAH) …