User profiles for K. Kitowska

Kamila Kitowska

dr, Gdański Uniwersytet Medyczny
Verified email at gumed.edu.pl
Cited by 589

Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases

…, P Bulau, D Zakrzewicz, KE Kitowska… - American journal of …, 2006 - atsjournals.org
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthesis.
ADMA is generated by catabolism of proteins containing methylated arginine residues, and its …

[HTML][HTML] FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors–implications for therapy of luminal breast cancer

…, M Braun, K Kitowska, K Mieczkowski… - Journal of Experimental …, 2019 - Springer
Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation
of steroid hormone receptors, have long been implicated in development of breast cancer …

Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA

P Bulau, D Zakrzewicz, K Kitowska… - … of Physiology-Lung …, 2007 - journals.physiology.org
… Kamila Kitowska … Zakrzewicz and K. Kitowska were supported by predoctoral fellowships
of the International Graduate Program Molecular Biology and Medicine of the Lung. …

Functional role and species-specific contribution of arginases in pulmonary fibrosis

K Kitowska, D Zakrzewicz… - … of Physiology-Lung …, 2008 - journals.physiology.org
… Although arginases have a significantly lower K m for l-arginine (2–20 mM range and 2–20
μM range for arginases and NOS, respectively), they exhibit a 1,000× higher V max …

[HTML][HTML] FGFR2-driven signaling counteracts tamoxifen effect on ERα-positive breast cancer cells

L Turczyk, K Kitowska, M Mieszkowska, K Mieczkowski… - Neoplasia, 2017 - Elsevier
Signaling mediated by growth factors receptors has long been suggested as one of the key
factors responsible for failure of endocrine treatment in breast cancer (BCa). Herein we …

[HTML][HTML] p38 mediates resistance to FGFR inhibition in non-small cell lung cancer

…, M Wieczorek, KM Lisowska, R Sadej, K Kitowska - Cells, 2021 - mdpi.com
FGFR signalling is one of the most prominent pathways involved in cell growth and development
as well as cancer progression. FGFR1 amplification occurs in approximately 20% of all …

Quantitative assessment of arginine methylation in free versus protein-incorporated amino acids in vitro and in vivo using protein hydrolysis and high-performance …

P Bulau, D Zakrzewicz, K Kitowska, B Wardega… - …, 2006 - Future Science
Arginine methylation constitutes a posttranslational modification dependent on the action of
protein arginine methyltransferases (PRMTs). Using S-adenosylmethionine as a methyl …

FGF7/FGFR2–JunB signalling counteracts the effect of progesterone in luminal breast cancer

K Mieczkowski, K Kitowska, M Braun… - Molecular …, 2022 - Wiley Online Library
We have recently demonstrated that fibroblast growth factor receptor 2 (FGFR2)‐mediated
signalling alters progesterone receptor (PR) activity and response of oestrogen receptor α (ER…

[HTML][HTML] Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells

D Piasecka, K Kitowska, D Czaplinska, K Mieczkowski… - Oncotarget, 2016 - ncbi.nlm.nih.gov
We have recently demonstrated that, fibroblast growth factor 2 (FGFR2), signalling via
ribosomal S6 kinase 2 (RSK2), promotes progression of breast cancer (BCa). Loss of …

[HTML][HTML] MET-Pyk2 axis mediates acquired resistance to FGFR inhibition in cancer cells

K Kitowska, M Gorska-Arcisz, D Antoun… - Frontiers in …, 2021 - frontiersin.org
Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of FGFR
amplification, chromosomal translocation, or mutations, is involved in both initiation and …