Inflammation, growth factors, and pulmonary vascular remodeling

…, S Eddahibi, SC Flores, F Grimminger… - Journal of the american …, 2009 - jacc.org
Inflammatory processes are prominent in various types of human and experimental pulmonary
hypertension (PH) and are increasingly recognized as major pathogenic components of …

[HTML][HTML] Mechanisms of disease: pulmonary arterial hypertension

…, HA Ghofrani, MR Wilkins, F Grimminger - Nature Reviews …, 2011 - nature.com
… , a phenomenon that can be tracked using 18 F-fluorodeoxyglucose ( 18 F-FDG). Cancers
typically show increased 18 F-FDG uptake and data suggest that proliferating pulmonary …

[HTML][HTML] Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond

HA Ghofrani, IH Osterloh, F Grimminger - Nature reviews Drug …, 2006 - nature.com
In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has
evolved from a potential anti-angina drug to an on-demand oral treatment for erectile …

[HTML][HTML] Sildenafil citrate therapy for pulmonary arterial hypertension

…, G Burgess, A Branzi, F Grimminger… - … England Journal of …, 2005 - Mass Medical Soc
Background Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic
guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate–…

[HTML][HTML] Riociguat for the treatment of chronic thromboembolic pulmonary hypertension

HA Ghofrani, AM D'Armini, F Grimminger… - … England Journal of …, 2013 - Mass Medical Soc
Background Riociguat, a member of a new class of compounds (soluble guanylate cyclase
stimulators), has been shown in previous clinical studies to be beneficial in the treatment of …

[HTML][HTML] Riociguat for the treatment of pulmonary arterial hypertension

HA Ghofrani, N Galič, F Grimminger… - … England Journal of …, 2013 - Mass Medical Soc
Background Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase
2 trial to be beneficial in the treatment of pulmonary arterial hypertension. Methods In this …

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

…, A Gunther, D Walmrath, W Seeger, F Grimminger - The Lancet, 2002 - thelancet.com
Grimminger FGrimminger F … HA Ghofrani, H Olschewski, W Seeger, and F
Grimminger participated in analysis and interpretation of data, and revision of the report. …

[HTML][HTML] Reversal of experimental pulmonary hypertension by PDGF inhibition

…, W Seeger, F Grimminger - The Journal of …, 2005 - Am Soc Clin Investig
Progression of pulmonary hypertension is associated with increased proliferation and migration
of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and involved in …

Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea: impact of continuous positive airway pressure therapy

…, K Mayer, W Seeger, F Grimminger - American journal of …, 2000 - atsjournals.org
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and
mortality. Free oxygen radicals have been implicated in the pathogenesis of cardiovascular …

Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension

…, N Weissmann, W Seeger, F Grimminger - Annals of internal …, 2002 - acpjournals.org
Background: Inhalation of the stable prostacyclin analogue iloprost is being studied for
treatment of pulmonary hypertension. The selective phosphodiesterase-5 inhibitor sildenafil has …