Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches

AR Schwartz, SP Patil, AM Laffan… - Proceedings of the …, 2008 - atsjournals.org
Obstructive sleep apnea is a common disorder whose prevalence is linked to an epidemic
of obesity in Western society. Sleep apnea is due to recurrent episodes of upper airway …

Adult obstructive sleep apnea: pathophysiology and diagnosis

SP Patil, H Schneider, AR Schwartz, PL Smith - Chest, 2007 - Elsevier
Obstructive sleep apnea (OSA) is a highly prevalent disease characterized by recurrent
episodes of upper airway obstruction that result in recurrent arousals and episodic …

Toward a causal model of cardiovascular responses to stress and the development of cardiovascular disease

AR Schwartz, W Gerin, KW Davidson… - Psychosomatic …, 2003 - journals.lww.com
Objective Cardiovascular reactivity is hypothesized to mediate the relationship between
stress and cardiovascular disease. We describe three considerations that are crucial for a …

Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea

…, AI Pack, LR Kline, PL Smith, AR Schwartz… - American Review of …, 2012 - atsjournals.org
Obstruction of the upper airway during sleep (OSAS) is widely treated by having patients self-administer
nasal continuous positive airway pressure (CPAP). To obtain objective evidence …

Sleep-disordered breathing and insulin resistance in middle-aged and overweight men

…, LI Katzel, AP Goldberg, AR Schwartz… - American journal of …, 2002 - atsjournals.org
Sleep-disordered breathing is a prevalent condition associated with impairment of daytime
function and may predispose individuals to metabolic abnormalities independent of obesity. …

An instrument to measure functional status outcomes for disorders of excessive sleepiness

…, G Maislin, DK Chugh, K Lyon, PL Smith, AR Schwartz… - Sleep, 1997 - academic.oup.com
This article reports the development of the functional outcomes of sleep questionnaire (FOSQ).
This is the first self-report measure designed to assess the impact of disorders of …

Effect of weight loss on upper airway collapsibility in obstructive sleep apnea1-3

AR Schwartz, AR Gold, N Schubert, A Stryzak - Am Rev Respir Dis, 1991 - atsjournals.org
Previous investigators have demonstrated in patients with obstructive sleep apnea that
weight reduction results in a decrease in apnea severity. Although the mechanism for this …

Upper airway pressure-flow relationships in obstructive sleep apnea

…, RA Wise, AR Gold, AR Schwartz… - Journal of applied …, 1988 - journals.physiology.org
We examined the pressure-flow relationships in patients with obstructive sleep apnea utilizing
the concepts of a Starling resistor. In six patients with obstructive sleep apnea, we applied …

Leptin prevents respiratory depression in obesity

…, CG Tankersley, AR Schwartz… - American journal of …, 1999 - atsjournals.org
Human obesity leads to an increase in respiratory demands. As obesity becomes more
pronounced some individuals are unable to compensate, leading to elevated arterial carbon …

A survey screen for prediction of apnea

G Maislin, AI Pack, NB Kribbs, PL Smith, AR Schwartz… - Sleep, 1995 - academic.oup.com
Questionnaire data from patients presenting at three sleep disorders centers were used to
develop and assess a screening tool for sleep apnea based on the reporting of the frequency …