Asthma is a disorder of the airways involving various inflammatory cells and mediators and
characterised by bronchial hyperresponsiveness, chronic inflammation and structural …

Key Points Asthma is a heterogeneous syndrome ranging from mild disease with barely
noticeable symptoms to very severe disease with constant symptoms that may greatly hinder …

Background Osteopontin (OPN) is a glycoprotein that has been associated with inflammation
and fibrosis. Severe refractory asthma (SRA) is characterised by an intense inflammatory …

Background Distinct inflammatory cellular phenotypes of severe refractory asthma (SRA)
have been reported. Fractional exhaled nitric oxide (FeNO) primarily is related to eosinophilic …

Intravesical administration of BCG is a relatively simple procedure used successfully in the
treatment of superficial transitional cell carcinoma of the urinary bladder. It is usually well …

Asthma is a heterogeneous disease usually characterised by chronic airway inflammation. It
is defined by a history of symptoms such as wheeze, shortness of breath, chest tightness …

Pathological features of chronic obstructive pulmonary disease (COPD) include lung
vascular remodeling and angiogenesis. Angiopoietin-1 (Ang-1), is an essential mediator of …

Background: Osteopontin (OPN) is a glycoprotein that has been associated with inflammation
and fibrosis. Recent published data suggest that OPN is increased in asthma and is …

An 80-year-old man developed granulomatous hepatitis, pneumonitis and sepsis after
receiving intravesicular BCG. The man was transferred to a hospital with acute respiratory and …

Background: Osteopontin (OPN) has been associated with inflammation and fibrosis. OPN
is increased in asthma and is related to the underlying severity and to features expressing …