Background Colorectal cancer (CRC) is the third most common cancer in the UK: incidence
increases with age, median age at diagnosis being over 70 years. Approximately 25% of …

Background: Multiple sclerosis (MS) is a progressive degenerative disease of the CNS with
a pattern of symptoms that depends on the type of disease and the site of lesions. As …

BACKGROUND In older age, reduction in physical function can lead to loss of independence,
the need for hospital and long-term nursing or residential home care, and premature death…

… Fiona Campbell, Mike Holmes, Emma Everson-Hock, Sarah Davis, Helen Buckley Woods,
Nana Anokye, Paul Tappenden and Eva Kaltenthaler … ‘Adherence’ describes the level and …

Background: Pioglitazone is a member of a recently developed class of glucose-lowering
agents, the thiazolidinediones, used in the treatment of type 2 diabetes mellitus. In the United …

… The addition of 5 mg/kg bevacizumab to 5-FU/FA resulted in a non-significant increase in
median OS of 3.7 (p = 0.16, primary end-point) within one study and an increase in median …

Background Haemolytic disease of the newborn affects the fetus or neonate, and results
from the transplacental passage of maternal allo-antibodies directed against fetal red cell …

This paper presents an application of a new methodological framework for undertaking
distributional cost‐effectiveness analysis to combine the objectives of maximising health and …

… Paul Tappenden1, … Paul Tappenden … Tappenden P, Eggington S, Nixon R, et al. Colorectal
cancer screening options appraisal: cost-effectiveness, cost-utility and resource impact of …

Objectives The objective of this report was to undertake a structured review and critical
appraisal of methods for the model-based cost–utility analysis of screening programmes. It also …