Peri-prosthetic osteolysis and subsequent aseptic loosening is the most common reason for
revising total hip replacements. Wear particles originating from the prosthetic components …

Background: Diabetic nephropathy (DN) is a frequent complication in patients with diabetes
mellitus. To find improved intervention strategies in this disease, it is necessary to …

Micro-vascular and renal complications in diabetic patients are a considerable clinical
challenge. In a previous study, we found a significant decrease in vascular endothelial growth …

… Doran 1 , Susan B. Connolly , Marie-Claire Greenan , Debra F. Higgins , Martin Leonard ,
Catherine Godson , Cormac T. … Curr Opin Nephrol Hypertens, 8 (1999), pp. 449-458 …

Newborn screening for the inborn error of metabolism, classical galactosaemia prevents life‐threatening
complications in the neonatal period. It does not however influence the …

A high incidence of decreased bone mineral density (BMD) has increasingly been associated
with HIV infection. In this study mesenchymal stem cell (MSC) and human osteoblast (hOB…

The Wnt/β‐catenin pathway is a major signaling cascade in bone biology, playing a key role
in regulating bone development and remodeling, with aberrations in signaling resulting in …

Background Osteoporosis, a disease of decreased bone mineral density represents a
significant and growing burden in the western world. Aging population structure and therapeutic …

Background The Wnt/β-catenin pathway is a major signaling cascade in bone biology, playing
a key role in bone development and remodeling. The objectives of this study were firstly, …

Chemokines are major regulators of the inflammatory response and have been shown to
play an important role in periprosthetic osteolysis. Titanium particles have previously been …