Some new, simple and efficient stereological methods and their use in pathological research and diagnosis

…, N MARCUSSEN, A Møller, K Nielsen, JR Nyengaard… - Apmis, 1988 - Wiley Online Library
Stereology is a set of simple and efficient methods for quantitation of three‐dimensional
microscopic structures which is specifically tuned to provide reliable data from sections. Within …

The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

…, N Marcussen, A Møller, K Nielsen, JR Nyengaard… - Apmis, 1988 - Wiley Online Library
The new stereological methods for correct and efficient sampling and sizing of cells and
other particles are reviewed. There is a hierarchy of methods starting from the simplest where …

Hyperglycemic pseudohypoxia and diabetic complications

…, KS Hasan, Y Ido, T Kawamura, JR Nyengaard… - Diabetes, 1993 - Am Diabetes Assoc
Vasodilation and increased blood flow are characteristic early vascular responses to acute
hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to …

Glomerular number and size in relation to age, kidney weight, and body surface in normal man

JR Nyengaard, TF Bendtsen - The Anatomical Record, 1992 - Wiley Online Library
The number and size of glomeruli in normal, mature human kidneys were estimated by a
direct and unbiased stereological method, the fractionator. The number was 617,000 on …

[PDF][PDF] Dynamics of cell generation and turnover in the human heart

…, T Malm, M Andrä, R Jashari, JR Nyengaard… - Cell, 2015 - cell.com
The contribution of cell generation to physiological heart growth and maintenance in
humans has been difficult to establish and has remained controversial. We report that the full …

Marked loss of myelinated nerve fibers in the human brain with age

L Marner, JR Nyengaard, Y Tang… - Journal of comparative …, 2003 - Wiley Online Library
The white matter is the structure of the brain that declines most with age—almost 30%, but
little is known about the age‐effect on the fibers that constitute the white matter. In the present …

[HTML][HTML] Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats

LL Woods, JR Ingelfinger, JR Nyengaard, R Rasch - Pediatric research, 2001 - nature.com
Restriction of maternal protein intake during rat pregnancy produces offspring that are
hypertensive in adulthood, but the mechanisms are not well understood. Our purpose was to …

The number of alveoli in the human lung

M Ochs, JR Nyengaard, A Jung, L Knudsen… - American journal of …, 2004 - atsjournals.org
The number of alveoli is a key structural determinant of lung architecture. A design-based
stereologic approach was used for the direct and unbiased estimation of alveolar number in …

[HTML][HTML] RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system

…, MB Hovgaard, A Schmitz, JR Nyengaard… - Molecular Therapy, 2006 - cell.com
This work introduces a novel chitosan-based siRNA nanoparticle delivery system for RNA
interference in vitro and in vivo. The formation of interpolyelectrolyte complexes between …

Tissue shrinkage and unbiased stereological estimation of particle number and size

KA Dorph‐Petersen, JR Nyengaard… - Journal of …, 2001 - Wiley Online Library
This paper is a review of the stereological problems related to the unbiased estimation of
particle number and size when tissue deformation is present. The deformation may occur …