Diagnosis and assessment of pulmonary arterial hypertension

…, MM Hoeper, JE Loyd, A Manes… - Journal of the American …, 2009 - jacc.org
The diagnosis and assessment of pulmonary arterial hypertension is a rapidly evolving area,
with changes occurring in the definition of the disease, screening and diagnostic techniques…

Definitions and diagnosis of pulmonary hypertension

…, D Khanna, M Kurzyna, D Langleben, A Manes… - Journal of the American …, 2013 - jacc.org
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥25 mm Hg
at rest, measured during right heart catheterization. There is still insufficient evidence to add …

The endothelin system in pulmonary arterial hypertension

N Galié, A Manes, A Branzi - Cardiovascular research, 2004 - academic.oup.com
Endothelin-1 (ET-1), a peptide produced primarily by vascular endothelial cells, was discovered
in 1980 and it was characterized as a powerful vasoconstrictor and mitogen for smooth …

[HTML][HTML] Inhaled iloprost for severe pulmonary hypertension

…, W Popov, HA Ghofrani, A Manes… - … England Journal of …, 2002 - Mass Medical Soc
Background Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of
prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and …

Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2

…, LJ Rubin, EM Horn, A Manes… - European …, 2004 - Eur Respiratory Soc
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor
antagonist and epoprostenol, a continuously infused prostaglandin, in the treatment of …

The paradoxical increase of Mediterranean extreme daily rainfall in spite of decrease in total values

…, R Romero, S Michaelides, A Manes - Geophysical …, 2002 - Wiley Online Library
Earlier reports indicated some specific isolated regions exhibiting a paradoxical increase of
extreme rainfall in spite of decrease in the totals. Here, we conduct a coherent study of the full…

[HTML][HTML] Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia

…, WC Nichols, J Berg, A Manes… - … England Journal of …, 2001 - Mass Medical Soc
Background Most patients with familial primary pulmonary hypertension have defects in the
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …

[PDF][PDF] BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension

…, J Newman, D Williams, N Galiè, A Manes… - The American Journal of …, 2001 - cell.com
Primary pulmonary hypertension (PPH) is a potentially lethal disorder, because the elevation
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …

Effects of the oral endothelin-receptorantagonist bosentan on echocardiographicand doppler measures in patients with pulmonary arterial hypertension

…, N Espinola-Zavaleta, G Rocchi, A Manes… - Journal of the American …, 2003 - jacc.org
Objectives : The purpose of this study was to investigate the effects of bosentan (125 or 250
mg twice daily) on echocardiographic and Doppler variables in 85 patients with World …

Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension

…, RN Channick, PM Hassoun, IM Lang, A Manes… - Journal of the American …, 2009 - jacc.org
The 4th World Symposium on Pulmonary Hypertension was the first international meeting to
focus not only on pulmonary arterial hypertension (PAH) but also on the so-called non-PAH …