Diagnosis and assessment of pulmonary arterial hypertension
…, MM Hoeper, JE Loyd, A Manes… - Journal of the American …, 2009 - jacc.org
The diagnosis and assessment of pulmonary arterial hypertension is a rapidly evolving area,
with changes occurring in the definition of the disease, screening and diagnostic techniques…
with changes occurring in the definition of the disease, screening and diagnostic techniques…
Definitions and diagnosis of pulmonary hypertension
Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure ≥25 mm Hg
at rest, measured during right heart catheterization. There is still insufficient evidence to add …
at rest, measured during right heart catheterization. There is still insufficient evidence to add …
The endothelin system in pulmonary arterial hypertension
N Galié, A Manes, A Branzi - Cardiovascular research, 2004 - academic.oup.com
Endothelin-1 (ET-1), a peptide produced primarily by vascular endothelial cells, was discovered
in 1980 and it was characterized as a powerful vasoconstrictor and mitogen for smooth …
in 1980 and it was characterized as a powerful vasoconstrictor and mitogen for smooth …
[HTML][HTML] Inhaled iloprost for severe pulmonary hypertension
…, W Popov, HA Ghofrani, A Manes… - … England Journal of …, 2002 - Mass Medical Soc
Background Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of
prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and …
prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and …
Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
…, LJ Rubin, EM Horn, A Manes… - European …, 2004 - Eur Respiratory Soc
The efficacy and safety of combining bosentan, an orally active dual endothelin receptor
antagonist and epoprostenol, a continuously infused prostaglandin, in the treatment of …
antagonist and epoprostenol, a continuously infused prostaglandin, in the treatment of …
The paradoxical increase of Mediterranean extreme daily rainfall in spite of decrease in total values
…, R Romero, S Michaelides, A Manes - Geophysical …, 2002 - Wiley Online Library
Earlier reports indicated some specific isolated regions exhibiting a paradoxical increase of
extreme rainfall in spite of decrease in the totals. Here, we conduct a coherent study of the full…
extreme rainfall in spite of decrease in the totals. Here, we conduct a coherent study of the full…
[HTML][HTML] Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
…, WC Nichols, J Berg, A Manes… - … England Journal of …, 2001 - Mass Medical Soc
Background Most patients with familial primary pulmonary hypertension have defects in the
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
[PDF][PDF] BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
…, J Newman, D Williams, N Galiè, A Manes… - The American Journal of …, 2001 - cell.com
Primary pulmonary hypertension (PPH) is a potentially lethal disorder, because the elevation
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …
of the pulmonary arterial pressure may result in right-heart failure. Histologically, the …
Effects of the oral endothelin-receptorantagonist bosentan on echocardiographicand doppler measures in patients with pulmonary arterial hypertension
…, N Espinola-Zavaleta, G Rocchi, A Manes… - Journal of the American …, 2003 - jacc.org
Objectives : The purpose of this study was to investigate the effects of bosentan (125 or 250
mg twice daily) on echocardiographic and Doppler variables in 85 patients with World …
mg twice daily) on echocardiographic and Doppler variables in 85 patients with World …
Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension
…, RN Channick, PM Hassoun, IM Lang, A Manes… - Journal of the American …, 2009 - jacc.org
The 4th World Symposium on Pulmonary Hypertension was the first international meeting to
focus not only on pulmonary arterial hypertension (PAH) but also on the so-called non-PAH …
focus not only on pulmonary arterial hypertension (PAH) but also on the so-called non-PAH …