Guidelines on asthma management recommend that in patients who still have symptoms on
treatment with low-dose inhaled corticosteroids the first step should be an increase in …

SummaryPulmonary colonisation with Pseudomonas cepacia in patients with cystic fibrosis
can be associated with increased morbidity and mortality. The modes of transmission of P …

The use of a combination inhaler containing budesonide and formoterol as both maintenance
and quick relief therapy (SMART) has been recommended as an improved method of …

Background Lung delivery of plasmid DNA encoding the CFTR gene complexed with a
cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to …

In cystic fibrosis (CF), mutation of the cystic fibrosis transmembrane conductance regulator (CFTR)
gene results in defective transepithelial ion transport, leading to life shortening …

Rationale: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term
treatments. Objectives: A randomized controlled trial assessing the efficacy of nebulized …

Background: The loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated
chloride conductance does not fully explain the diverse pathologies evident in patients …

… All bronchoscopy procedures were performed by the same bronchoscopist (AP Greening).
On average, 76% of instilled NaCl solution was recovered. Recovered fluid and cells were …

Background: Lung clearance index (LCI) is a sensitive marker of early lung disease in children
but has not been assessed in adults. Measurement is hindered by the complexity of the …

Objectives To assess the effect of montelukast versus salmeterol added to inhaled fluticasone
propionate on asthma exacerbation in patients whose symptoms are inadequately …