The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In this review, we summarize the upstream and downstream players from Rho GTPases that are mainly involved in actin polymerization leading to cell motility and potentially playing a role in cancer cell metastasis.
Keywords: Actin; Cancer; Motility; PI3K; Rho GTPases.
Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.