Elevation of pulmonary artery pressure as a complication of nilotinib therapy for chronic myeloid leukemia

Int J Hematol. 2012 Jul;96(1):132-5. doi: 10.1007/s12185-012-1103-0. Epub 2012 May 26.

Abstract

We present the case of a 72-year-old male with chronic phase myeloid leukemia. Elevation of the pulmonary artery pressure due to nilotinib therapy was noted. This effect on pulmonary artery pressure was nilotinib dose dependent.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Echocardiography, Doppler
  • Familial Primary Pulmonary Hypertension
  • Humans
  • Hypertension, Pulmonary / chemically induced*
  • Hypertension, Pulmonary / diagnosis*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Male
  • Natriuretic Peptide, Brain / blood
  • Peptide Fragments / blood
  • Pyrimidines / administration & dosage
  • Pyrimidines / adverse effects*
  • Pyrimidines / therapeutic use

Substances

  • Antineoplastic Agents
  • Peptide Fragments
  • Pyrimidines
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • nilotinib