Abstract
Hedgehog (HH) and TGF-β signals control various aspects of embryonic development and cancer progression. While their canonical signal transduction cascades have been well characterized, there is increasing evidence that these pathways are able to exert overlapping activities that challenge efficient therapeutic targeting. We herein review the current knowledge on HH signaling and summarize the recent findings on the crosstalks between the HH and TGF-β pathways in cancer.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Epithelial-Mesenchymal Transition
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Fibrosis / metabolism
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Hedgehog Proteins / metabolism*
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Humans
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Kruppel-Like Transcription Factors / metabolism
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Ligands
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Mice
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Models, Biological
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Neoplasms / metabolism*
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Nuclear Proteins / metabolism
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Oncogene Proteins / metabolism
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RNA Processing, Post-Transcriptional
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Rats
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Signal Transduction
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Trans-Activators / metabolism
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Transforming Growth Factor beta / metabolism*
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Zinc Finger Protein GLI1
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Zinc Finger Protein Gli2
Substances
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GLI2 protein, human
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Hedgehog Proteins
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Kruppel-Like Transcription Factors
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Ligands
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Nuclear Proteins
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Oncogene Proteins
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Trans-Activators
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Transforming Growth Factor beta
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Zinc Finger Protein GLI1
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Zinc Finger Protein Gli2