Increased oral bioavailability of itraconazole and its active metabolite, 7-hydroxyitraconazole, when coadministered with a vitamin C beverage in healthy participants

J Clin Pharmacol. 2011 Mar;51(3):444-51. doi: 10.1177/0091270010365557. Epub 2010 Apr 16.
No abstract available

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antifungal Agents / adverse effects
  • Antifungal Agents / blood
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacokinetics*
  • Ascorbic Acid / administration & dosage*
  • Beverages / analysis*
  • Biological Availability
  • Biotransformation
  • Cross-Over Studies
  • Female
  • Food-Drug Interactions*
  • Half-Life
  • Humans
  • Itraconazole / adverse effects
  • Itraconazole / analogs & derivatives*
  • Itraconazole / blood
  • Itraconazole / chemistry
  • Itraconazole / pharmacokinetics*
  • Male
  • Miconazole / blood
  • Miconazole / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Tandem Mass Spectrometry
  • Young Adult

Substances

  • Antifungal Agents
  • hydroxyitraconazole
  • Itraconazole
  • Miconazole
  • Ascorbic Acid