Abstract
Interleukin-17 (IL-17A) is a pro-inflammatory cytokine that has recently been implicated in pathogenesis of Langerhans Cell Histiocytosis (LCH), a potentially fatal disease characterized by lesions including CD207+ (langerin +) histiocytes. However, in this study we were unable to identify IL-17A gene expression in Langerhans cell lesions, and plasma levels of IL-17A did not correlate with disease activity. Therefore, this study does not support a central role for IL-17A in LCH pathogenesis.
Publication types
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Comment
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, CD / metabolism*
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Biopsy
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Cell Division
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Cell Survival
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Dendritic Cells / pathology
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Enzyme-Linked Immunosorbent Assay
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Gene Amplification
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Gene Expression Regulation
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Histiocytosis, Langerhans-Cell / pathology
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Histiocytosis, Langerhans-Cell / physiopathology*
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Humans
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Interleukin-17 / blood
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Interleukin-17 / genetics*
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Lectins, C-Type / metabolism*
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Mannose-Binding Lectins / metabolism*
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Polymerase Chain Reaction
Substances
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Antigens, CD
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CD207 protein, human
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Interleukin-17
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Lectins, C-Type
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Mannose-Binding Lectins