Case of multiple myeloma mimicking an infectious disease with fever, intrahepatic cholestasis, renal failure, and pulmonary insufficiency

Francesco S Vella; Barbara Simone; Gianluigi Giannelli; MariaTeresa Pesolo; Giuseppe Ingravallo; Antonia Gentile; Salvatore Antonaci

doi:10.1002/ajh.10257

Case of multiple myeloma mimicking an infectious disease with fever, intrahepatic cholestasis, renal failure, and pulmonary insufficiency

Am J Hematol. 2003 Jan;72(1):38-42. doi: 10.1002/ajh.10257.

Authors

Francesco S Vella¹, Barbara Simone, Gianluigi Giannelli, MariaTeresa Pesolo, Giuseppe Ingravallo, Antonia Gentile, Salvatore Antonaci

Affiliation

¹ Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, University of Bari, Policlinico, Bari, Italy. diceglie@intmed.uniba.it

PMID: 12508267
DOI: 10.1002/ajh.10257

Abstract

We describe a case of multiple myeloma (MM) presenting with high fever, inflammatory chemistry abnormalities, simultaneous acute renal failure, cholestatic hepatitis, and acute lung failure. The extremely aggressive course and pulmonary involvement in the form of pulmonary alveolar proteinosis (PAP) are discussed, stressing the unusual nature of the findings and the variable picture of MM.

Publication types

Case Reports
Review

MeSH terms

Acute Kidney Injury / etiology*
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Anemia, Hypochromic / etiology
Aspartate Aminotransferases / blood
C-Reactive Protein / analysis
Cholestasis, Intrahepatic / etiology*
Diagnosis, Differential
Fatal Outcome
Fever / etiology*
Humans
Infections / diagnosis
L-Lactate Dehydrogenase / blood
Male
Middle Aged
Multiple Myeloma / blood
Multiple Myeloma / complications
Multiple Myeloma / diagnosis*
Pulmonary Alveolar Proteinosis / etiology*

Substances

C-Reactive Protein
L-Lactate Dehydrogenase
Aspartate Aminotransferases
Alanine Transaminase
Alkaline Phosphatase