Sjögren's syndrome, cavitating lung disease and high sustained levels of antibodies to serine proteinase 3

Scand J Rheumatol. 2000;29(4):267-9. doi: 10.1080/030097400750041442.

Abstract

A case is described involving Sjögren's syndrome, high sustained levels of antibodies to serine proteinase 3, and cavitating lung disease. Possible diagnoses accounting for this unusual combination include a novel association of Sjögren's syndrome and Wegener's granulomatosis (suggested by the high and sustained levels of antibodies to serine proteinase 3) or a rare presentation of bronchiolitis obliterans organising pneumonia. Identification of the true nature of the patients illness facilitated more active management and a swift resolution of the clinical problem.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Autoantibodies / blood*
  • Cryptogenic Organizing Pneumonia / complications
  • Cryptogenic Organizing Pneumonia / diagnosis*
  • Cryptogenic Organizing Pneumonia / drug therapy
  • Diagnosis, Differential
  • Drug Therapy, Combination / therapeutic use
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology*
  • Radiography, Thoracic
  • Serine Endopeptidases / immunology*
  • Sjogren's Syndrome / blood
  • Sjogren's Syndrome / diagnosis*
  • Sjogren's Syndrome / immunology
  • Tomography, X-Ray Computed

Substances

  • Anti-Bacterial Agents
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Serine Endopeptidases