Original ArticleTracheobronchial Amyloidosis
Section snippets
PATIENTS AND METHODS
A complete computer-based search was performed to identify patients with a diagnosis of tracheobronchial amyloidosis presenting at the Mayo Clinic in Rochester, Minn, from 1973 to 1999 We reviewed the medical records of 17 patients with tracheobronchial amyloidosis to examine the clinical presentation, diagnostic procedures, pathologic diagnosis, treatment, and outcome of the disease. We also reviewed the bronchoscopic records to discern the description of the appearance and character of the
RESULTS
Between 1973 and 1999, 17 patients (9 women and 8 men) with tracheobronchial amyloidosis were evaluated (Table 1). Their ages at initial diagnosis ranged between 29 and 85 years, with the mean age being 56.6 years. Common symptoms were dyspnea, cough, hemoptysis, and hoarseness. The average duration of symptoms at initial presentation was 33 weeks, ranging from 1 week (a 39-year-old man with hemoptysis) to 2 years (2 women, age 49 and 51 years). In 5 patients, the diagnosis was made before they
DISCUSSION
Although similar in the aberrant nature of amyloid fibril deposition, several biochemically distinct forms of amyloidosis exist.1 Reactive amyloidosis (AA amyloidosis) is usually seen in response to an underlying inflammatory process and has been associated with familial Mediterranean fever and tuberculosis. This form of amyloidosis seldom leads to clinical respiratory disease. Several other forms of amyloidosis exist that are considered subtypes of hereditary amyloidosis, usually involving the
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