Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Severe Pulmonary Hypertension in a Patient with Systemic Lupus Erythematosus and Minimal Lupus Activity
Nobutoshi KAWAMURAHiroyuki TSUTSUIKae FUKUYAMAShunji HAYASHIDANIGeorge KOIKEKensuke EGASHIRAYasunobu ABEHidetaka YAMAMOTOMasazumi TSUNEYOSHIAkira TAKESHITA
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2002 Volume 41 Issue 2 Pages 109-112

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Abstract

Pulmonary hypertension (PH) sometimes occurs in patients with systemic lupus erythematosus (SLE). We report a case of 51-year-old-woman with PH associated with SLE. She had been diagnosed as SLE on the basis of pericardial effusion, hematological disorder, positive antinuclear antibody, and hypocomplementemia. Despite minimal lupus activity, she had marked elevation of pulmonary arterial pressure (101/53 mmHg) and decreased cardiac index (1.5 /lmin/m2). Symptoms related to PH were progressive under treatment with oral corticosteroids, oxygen, calcium antagonists, and warfarin. After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity.
(Internal Medicine 41:109-112, 2002)

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© The Japanese Society of Internal Medicine
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