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Pharmacokinetic Optimization of Immunosuppressive Therapy in Thoracic Transplantation: Part II

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Abstract

Part I of this article, which appeared in the previous issue of the Journal, reviewed calcineurin inhibitors —ciclosporin and tacrolimus. In part II, we review the pharmacokinetics and therapeutic drug monitoring of mycophenolate and mammalian target of rapamycin inhibitors — sirolimus and everolimus — in thoracic transplantation, and we provide an overall discussion and suggest various areas for future study.

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Acknowledgements

This work was supported by Limoges University Hospital and the French Patients’ Association ‘Vaincre la Mucoviscidose’ [Win against Cystic Fibrosis]. Pierre Marquet has received consultancies and honoraria from Roche and Novartis and research grants from Roche, Novartis and Astellas. Caroline Monchaud has no conflicts of interest that are directly relevant to the contents of this review.

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  1. INSERM Unit 850, CHU Limoges, University of Limoges, Limoges, France

    Caroline Monchaud &  Pierre Marquet

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  1. Caroline Monchaud
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Correspondence to Pierre Marquet.

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Monchaud, C., Marquet, P. Pharmacokinetic Optimization of Immunosuppressive Therapy in Thoracic Transplantation: Part II. Clin Pharmacokinet 48, 489–516 (2009). https://doi.org/10.2165/11317240-000000000-00000

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