Chest
Original Research: ASTHMAAllergic Rhinitis and Sinusitis in Asthma: Differential Effects on Symptoms and Pulmonary Function
Section snippets
Participants
We evaluated baseline cross-sectional data obtained from two cohorts of patients enrolled in the ALA-ACRC Safety of Inactivated Influenza Vaccine in Asthma in Adults and Children (SIIVA) and Effectiveness of Low Dose Theophylline as Add-on Treatment in Asthma (LODO) trials. The primary results of the SIIVA trial have been published10; those of the LODO trial have been submitted for publication. In brief, the SIIVA trial was a multicenter, double-blind, placebo-controlled, crossover study to
Baseline Demographics
The SIIVA trial enrolled 2,031 participants (age range, 3 to 83 years). The distribution of race and age is shown in Table 1. The LODO trial enrolled 488 participants ≥ 15 years old; age and race distribution are shown in Table 1. The SIIVA cohort included significantly more children: 38% of the participants were < 20 years old, compared with 10% in the LODO trial.
Prevalence of Allergic Rhinitis and Sinusitis
Allergic rhinitis and sinusitis were the most common comorbidities reported in these participants; together, they affected 73% of
DISCUSSION
In our study, self-reported allergic rhinitis and sinusitis were very common in asthma. GERD, female gender, and white race were particularly associated with both allergic rhinitis and sinusitis. Both allergic rhinitis and sinusitis were associated with more severe symptoms in those with more severe asthma at baseline; in one cohort, sinusitis (but not allergic rhinitis) was associated with increased exacerbations. Participants with allergic rhinitis and sinusitis tended to have higher lung
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None of the authors have any conflicts of interest in the content of this article.
Funding was provided by the American Lung Association and grant K23 RR019965.