Chest
ReviewsThe Role of Anticholinergics in Acute Asthma Treatment: An Evidence-Based Evaluation
Section snippets
Materials and Methods
The studies found were evaluated based on the following ranking for level of evidence59: The best level (level I) included results from large, randomized, controlled trials or systematic reviews of randomized trials. The next level of evidence (level II) would be small, randomized, clinical trials that have insufficient numbers of patients to achieve statistically significant results. Finally, cohort (level III), case control (level IV), and case series (level V) would be considered lower
Pediatric Studies
The search of the previously described databases produced two systematic reviews about the efficacy of ipratropium bromide and anticholinergic agent use in children with acute asthma.
In the review by Osmond and Klassen,65 six randomized controlled trials (285 patients) involving pediatric and adolescent patients (age range, 1 to 17 years) with acute asthma were examined to determine the effect of treatment (ie, ipratropium bromide plus β-agonists vs β-agonists alone) on clinical and physiologic
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