Chest
Clinical InvestigationsCOPDLung Volumes in 4,774 Patients With Obstructive Lung Disease
Section snippets
Materials and Methods
The study population was comprised of adult outpatients of> 30 years old who were referred to the Mayo Clinic outpatient pulmonary function (PF) laboratory in Rochester, MN between January 1990 and July 1994, and who had completed measurements of spirometry and static lung volumes. All of the patients with a prebronchodilator FEV1/FVC of > 0.70 were excluded from the study. The FEV1, the FVC, and the slow vital capacity (VC) were measured according to ATS recommendations3 using a model 1070
Results
There were 4,774 adult patients who met the entry criteria of an FEV1/FVC of < 0.70; 61% were men, and the mean age was 69 (see Fig 1 for the age distribution). At the time of testing, 908 patients (19%) reported a diagnosis of asthma, 1,099 patients (23%) reported a diagnosis of emphysema or COPD, 70 patients (1.5%) reported chronic bronchitis, 31 patients (0.6%) reported anα 1-antiprotease (AAP) deficiency, and 56% did not report having a respiratory disease. More than one respiratory
Discussion
In this large retrospective study of patients referred to a single PF laboratory, we have confirmed that hyperinflation of lung volumes is associated with the degree of airway obstruction. However, the strength of this association, as well as other clinical correlates, vary considerably according to whether “hyperinflation” is defined as a high RV/TLC, a high RV, or a high TLC. The RV or the RV/TLC are much more sensitive than the TLC to the degree of airways obstruction (see Figs 2, 3,4). As
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